急性白血病化疗前后检测血清α1AG意义.docVIP

急性白血病化疗前后检测血清α1AG意义 　 作者：李萍，张代民，王化芬，崔庆 【摘要】 目的 探讨急性白血病(AL)患者血清α1酸性糖蛋白(α1AG)的水平及其临床意义。方法 选择51例急性白血病初治患者及11例复发患者，采用免疫透射比浊法测定其血清中α1酸性糖蛋白的含量，并与正常对照组比较。结果 AL初治组及复发组血清α1AG水平均明显高于正常人对照组水平， 差异有非常显著性意义(t=23．658，Plt;0．001)； 15例完全缓解(CR)患者血清α1AG水平均明显下降， 与正常对照组相比较， 差异均无显著性意义(t=0．776，Pgt;0．05)， 与其化疗前血清α1AG水平比较， 结果差异显著(t=28．799， Plt;0．001)； 急性淋巴细胞白血病(ALL)难治组血清α1AG水平均明显高于非难治组， 差异具有显著性意义(t=16．167，Plt;0．001)。急性髓细胞性白血病(AML)难治组血清α1AG水平均高于非难治组水平，且差异均具有统计学意义(t=16．672，Plt;0．001)。结论 检测血清α1AG水平对于监测急性白血病的化疗效果及复发有一定临床价值。 【关键词】 α1酸性糖蛋白；白血病；急性 　　Abstract： Objective To study serum level of α1acid glycoprotein (α1AG) in the patients with acute leukemia (AL) and its clinical significance.Methods A total of 51 patients with AL before treatment and 11 relapsing patients were selected. Their serum level of α1AG was measured and compared with that of normal controls. Results Serum level of α1AG was significantly higher in the patients with AL before treatment and in the relapsing patients than in the normal controls (t=23.658, Plt;0.001). The serum α1AG level of 15 complete remission (CR) patients decreased significfintly, and the difference between CR group and the normal group was not significant (t=0.776,Pgt;0.05). The serum α1AG level of refractory acute lymphocyte leukemia (ALL) patients were significantly higher than that of the remission group, and the difference between them was significant (t=16.167,Plt;0.001). The serum α1AG level of refractory acute myelogenous leukemia (AML) patients was significantly higher than that of the remission group, and the difference between them was significant (t=16.672, Plt;0.001). Conclusion Serum α1AG can be used for detecting clinical features and evaluating curative effect in the patients with AL. 　　Key words： α1acid glycoprotein; leukemia; acute 血清α1酸性糖蛋白(α1acid glycoprotein)是由肝脏合成，在血清中含糖量最高、酸性最强的单链糖蛋白，是一种急性时相反映蛋白。正常人血清中含量较低，但在感染急性期和恶性肿瘤等病理状态下其浓度明显升高，并与患者的治疗进程有关。本研究对51例急性白血病初治患者、11例复发患者血清α1AG的水平进行了检测，以探讨白血病患者血清α1AG的水平变化与疗效的关系。