第十九章 代谢调空--王镜岩《生物化学》第三版笔记(完美打印版)（The nineteenth chapter, metabolic regulation - Wangs biochemistry third edition notebook (perfect print edition)）.docVIP

第十九章 代谢调空--王镜岩《生物化学》第三版笔记(完美打印版)（The nineteenth chapter, metabolic regulation - Wangs biochemistry third edition notebook (perfect print edition)） The nineteenth chapter is metabolic adjustment Section 1 links between metabolic pathways Metabolic network (a) the relationship between sugar, fat and protein, linked by 6-phosphogluconate, pyruvate and acetyl coenzyme A three intermediate. Between lipid, glycerol, carbohydrate and protein can be transformed into each other, fatty acids in plants and micro-organisms through the glyoxylate cycle by acetyl coenzyme A synthesis of succinic acid, and then converted to carbohydrate or protein, but the animal does not exist the glyoxylate cycle, generally not by acetyl coenzyme A production of sugar and protein. (two) the relationship between nucleic acids and metabolism: nucleic acids are not important carbon sources, nitrogen sources and energy sources, but nucleic acids can affect the composition and metabolic types of cells by controlling the synthesis of proteins. Many nucleotides play an important role in metabolism, such as ATP, coenzyme and so on. On the other hand, the metabolism of nucleic acids is also influenced by other substances, especially proteins. (three) all kinds of substances affect each other, transform and link closely with each other in metabolism. The three carboxylic acid cycle is not only a common metabolic pathway for various substances, but also a channel for their interaction. Two. The unidirectional nature of catabolism and anabolism Although the enzymatic reaction is reversible, metabolic processes are unidirectional in the organism. The metabolism of some key parts is catalyzed by different enzymes, positive reactions and reverse reactions. This allows the two reactions to be in a thermodynamic state of interest. In general, the decarboxylation of a acid, the reaction catalyzed by kinase and carboxylation reaction are irreversible. These reactions are often tightly regulated and become critical