注射用维库溴铵（Vecuronium Bromide for Injection）.docVIP

注射用维库溴铵（Vecuronium Bromide for Injection） The common name of Vecuronium Bromide for Injection Name used before English name VECURONIM, BROMIDE, FOR, INJECTION Pinyin name ZHUSHEYEYONG WEIKUXIUAN Drug category; anaesthetic adjuvant White freeze dried powder. This product is a single pharmacological quaternary ammonium steroid effect of nondepolarizing muscle relaxants, structure and pancuronium are similar, while blocking between nerve terminals and muscle conduction through competition with acetylcholine nicotinic receptor in striated muscle motor end plate. Unlike depolarizing neuromuscular blocking agents such as succinylcholine, this product does not cause fibrillation of muscle fibers. Intravenous injection of 0.08 to 0.1mg/kg1 minutes, effective, 3~5 minutes peak, maintenance time of 30~90 minutes. Muscle relaxation effect intocostrin 3 times stronger; without blocking the role of the vagus nerve, because vecuronium did not cause increased heart rate, so it is suitable for myocardial ischemia and heart disease, but the application of vagus nerve excited drugs and? - blockers are prone to bradycardia. This product releases histamine weakly and has bronchospasm and anaphylaxis, but it is rare. This product does not pass placenta. Pharmacokinetics was rapidly distributed after intravenous administration, mainly distributed in the extracellular fluid, and T1/2a (distribution half-life) was about 2 minutes. Mainly metabolized by the liver to 3- hydroxy derivatives, about 5%, retained part of the activity (about 50% of the prototype drug), the drug prototype and metabolites are mainly excreted by bile. About 40% to 80% in the form of single quaternary ammonium, excreted by bile, and excreted from 15% to 30% through the kidneys. T1/2a (elimination half-life) about 30~80 minutes. Renal failure can be compensated by the elimination of the liver. Cardiovascular disease, advanced age, edema, etc. lead to increased distribution capacity, which can prolong the onset time. I