几种药物对高原脱适应者自由基代谢影响.docVIP

几种药物对高原脱适应者自由基代谢影响 　 作者：王引虎　崔建华　张西洲 【关键词】 高原病 　　【摘要】 目的 探讨银杏叶片、复方红景天、复方党参和刺五加片对高原脱适应者自由基代谢的影响。方法 将驻守海拔5170m 1年的健康青年57人于返回平原前5天随机分为5组，分别口服银杏叶片（12人）、复方红景天（12人）、刺五加（11人）、复方党参（11人）和安慰剂（11人）,返回平原后第7天停药。停药后清晨采空腹静脉血，检测血中丙二醛（MDA）、超氧化物歧化酶（SOD）、一氧化氮（NO）及其合酶（NOS）的浓度。结果 复方红景天组、复方党参组及银杏叶片组较安慰剂组SOD、NO、NOS均增高，MDA降低（P＜0.05或P＜0.01）。刺五加组较银杏叶片组SOD降低，差异有显著性（P＜0.05）；较复方红景天组和复方党参组MDA增高，NO、NOS降低，差异有显著性（P＜0.05）。其余无统计学意义（P＞0.05）。结论 银杏叶片、复方红景天和复方党参均具有减轻高原脱适应者机体脂质过氧化、降低再供氧损伤的功效。药物预防和治疗高原脱适应方法简便，适合在基层高原部队和其他人群中推广应用。 　　【关键词】 高原病；化学预防；自由基 　　The effects of several different medicines on free radical metabolism of de-adaptation to high altitude 　　【Abstract】 Objective To investigate the effects of Gingkgo biloba，Rhodiola，Ciwujia Pian，Compound Dangshen on free radical metabolism of de-adaptation to high altitude.Methods In a randomized controlled study，5 days before they returned plain，57 youths defended at 5170m for one year were divided into 5 groups:12 persons in Gingkgo biloba group，12 persons in Rhodiola group，11 persons in Ciwujia group，11 persons in Compound Dangshen group and 11 persons in placebo group.5 groups take Gingkgo biloba，Rhodiola，Ciwujia Pian，Compound Dangshen and placebo until arrived for 1 week.MDA，SOD，NO and it is synthase（NOS） were measured after they quit the drugs.Results SOD，NO，NOS were increased in Rhodiola and Compound Dangshen group，MDA were reduced when compared with placebo group （Plt;0.05 or Plt;0.01）.SOD were reduced significant in Ciwujia group compared with Gingkgo biloba group（Plt;0.05），MDA increased and NO，NOS were reduced in Ciwujia group compared with Rhodiola and Compound Dangshen group，the differences were significantly（Plt;0.05）.There were not significant difference between other groups （Pgt;0.05）.Conclusion Gingkgo biloba，Rhodiola and Compound Dangshen can alleviate lipid overoxidation，reduce re-oxygen-supply damages.Medicines prevent and cure de-adaptation to high altitude is convenient，it fit to applicata at military basic units and other crowds. 　　【Key w