盐酸氨溴索联合川芎嗪改善慢性阻塞性肺疾病临床疗效观察.docVIP

盐酸氨溴索联合川芎嗪改善慢性阻塞性肺疾病临床疗效观察 　【关键词】 慢性阻塞性肺疾病；盐酸氨溴索；川芎嗪；肺功能 ［摘要］ 目的 评价盐酸氨溴索（沐舒坦）联合川芎嗪对慢性阻塞性肺疾病（COPD）急性发作的疗效。方法 74例患者随机分组，测定基础肺功能。治疗组38例给予沐舒坦注射液15 mg+川芎嗪雾化溶液40 mg+NS 30 ml雾化吸入20 min，每日2次；对照组36例给予常规治疗。于治疗后第14天评价临床治疗效果并检测肺功能参数。结果 治疗后两组患者的咳嗽、咳痰及喘息症状明显好转，两组间治疗有效率比较差异有显著性（P＜0.05）；COPD患者在治疗前肺功能均有明显下降，两组差异无显著性。治疗后肺功能都有不同程度改善，但对照组与治疗前相比差异无显著性，治疗组与治疗前相比差异有非常显著性（P＜0.01），两组治疗后相比差异有非常显著性（P＜0.01）。结论 盐酸氨溴索（沐舒坦）联合川芎嗪雾化吸入有利于慢性阻塞性肺疾病急性发作患者临床症状的控制及肺功能的改善。 ［关键词］ 慢性阻塞性肺疾病；盐酸氨溴索；川芎嗪；肺功能 Clinical effect of mucosolvan and ligustrazine on chronic obstructive pulmonary disease ［Abstract］ Objective To evaluate the clinical effect of mucosolvan and ligustrazine on the acute attack of chronic obstructive pulmonary disease. Methods Seventyfour cases of patients with COPD were divided into treatment and control groups in random.Conventional therapy were used in two groups,mucosolvan 30 mg and ligustrazine 40 mg were used only in treatment group.Clinical appraisal and pulmonary function were determined after two weeks.Results There were remarkable improvement on the clinical symptoms in two groups.There were remarkable difference of the effective rates between treatment and control groups after two weeks in the clinical symptoms（P＜0.05）.There were no remarkable difference of pulmonary function in two groups before treatment.There were difference improvement of the pulmonary function after treatment in two groups.But there were no remarkable difference compared with pretherapy in control groups.The were remarkable difference compared with pretherapy intreatment groups.And there were remarkable difference of the pulmonary function after treatment in two groups（P＜0.05）. Conclusion It is beneficial to control clinical symptoms and improve pulmonary function that the inhalation of mucosolvan combinated with ligustrazine in the acute attack of COPD. ［Key words］ chronic obstructive pulmonary disease;mucosolvan;ligustrazine;pulmonary function 慢性阻塞性肺疾病（chronic obstrucitive pulmonary disease,COPD）是呼吸系统常见