注射用阿莫西林钠克拉维酸钾（Amoxicillin Sodium and Clavulanate Potassium for Injection）.docVIP

注射用阿莫西林钠克拉维酸钾（Amoxicillin Sodium and Clavulanate Potassium for Injection） Amoxicillin Sodium and Clavulanate Potassium for Injection (Amoxicillin, Sodium, and, Injection, Clavulanate, Potassium, for, etc) (East yuan, Anne, Leipziger, Joe) This product is a compound preparation, its components are amoxicillin sodium and clavulanate potassium, the ratio is 5: 1. [traits] This product is white or white powder. [pharmacology and toxicology] This product is a compound preparation of amoxicillin sodium and clavulanate potassium. Amoxicillin is broad-spectrum penicillin, potassium clavulanate itself only weak antibacterial activity, but inhibitory effect of strong broad-spectrum B lactam enzyme combination, can protect against amoxicillin B lactam enzyme hydrolysis. The antibacterial spectrum of this product is the same as amoxicillin, and it has expanded. Have a good effect on the enzyme production of Staphylococcus aureus, Staphylococcus aureus, coagulase negative Staphylococcus and Enterococcus, for some B producing enzyme in intestinal bacteria, bacteria liver, Haemophilus influenzae, Moraxella Mora bacteria, Bacteroides fragilis has better antibacterial activity. This product has no effect on Enterobacteriaceae and Pseudomonas such as methicillin resistant Staphylococcus and Enterobacter and other chromosomal mediated enzymes. [pharmacokinetics] Intravenous administration of this product 1.2g (amoxicillin, 1g and clavulanic acid, 0.2g), amoxicillin and clavulanic acid immediately reached the peak concentration of blood (Cmax). The pharmacokinetics were consistent with the two compartment open model. The blood elimination half-life (t1/2b) of amoxicillin was (1.03 + 0.11) h, and the blood elimination half-life (t1/2b) of clavulanic acid was (0.838 + 0.04) hours. The serum protein of two drugs had lower binding rate, about 70% of the free state of the goods found in the serum, amoxicillin and clavulanic acid were discharged in high concentrations in the urine, 8 hours u