MR医学影像文献Mao-2016-Correlation between neurochemical met.pdfVIP

Psychiatry and Clinical Neurosciences 2016 doi:10.1111/pcn.12372 Psychiatry and Clinical Neurosciences 2016; 70: 167–174 doi:10.1111/pcn.12372 Regular Article Correlation between neurochemical metabolism and memory function in adolescent patients with depression: A multi-voxel 1H magnetic resonance spectroscopy study Ning Mao, MD,1† Junfang Fang, MD,2† Haizhu Xie, MD, PhD,1 Xinjiang Liu, MD, PhD,2 Xingyue Jiang, MD, PhD,2 Guangbin Wang, MD, PhD,3 Minghu Cui, MD, PhD,2 Bin Wang, MD, PhD2 * and Qiang Liu, MD, PhD3 * 1Department of Radiology, Yantai Yuhuangding Hospital, 2Binzhou Medical University, Yantai, and 3Shandong Medical Imaging Research Institute, Shan Dong University, Jinan, China Aims: We utilized multi-voxel proton magnetic reso- matter (P 0.05). No biochemical differences were 1 identified in the bilateral anterior cingulate gray nance spectroscopy ( H-MRS) to detect biochemical abnormalities in dorsolateral prefrontal white matter matter between the two groups. Nevertheless, the and anterior cingulate gray matter and to determine depressed patients showed significantly lower the correlation of biochemical changes with memory memory quotient than controls (P 0.05). The function in depressed adolescents. NAA/Cr ratio in dorsolateral prefrontal white matter positively correlated with memory quotient (left: Methods: A total of 24 depressed patients and 23 P 0.01; right: P 0.05). healthy controls were enrolled in this study. MRS was performed