甘薯sporamin蛋白对结直肠癌的抑制作用研究进展-西部人居环境学刊.pdfVIP

6 10 Vol. 6 No. 10 2015 10 Journal of Food Safety and Quality Oct. , 2015 sporamin 李鹏高* (, 100069) 摘 要: (colorectal cancer, CRC) CRC Sporamin , CRC , (insulin-like growth factors, IGFs)CRC IGF , IGF1IGF2 , IGFs , sporamin CRC , IGFs , sporamin CRC 关键词: ; ; sporamin ; ; Research progress on the inhibition of colorectal cancer by sweet potato protein sporamin * LI Peng-Gao (School of Public Health, Capital Medical University, Beijing 100069, China) ABSTRACT: Colorectal cancer (CRC) is a malignance of the colon and rectal epithelium that usually occurs in the presence of a variety of environmental carcinogens and genetic factors. The high-fat, high-energy, low-fiber diet, the sedentary life style and obesity are the risk factors of CRC. Sporamin is a unique protein that is contained in the tuberous roots of sweet potato and is a kind of trypsin inhibitor. It has been shown to be able to inhibit the differentiation of preadipocyte and reduce the gene expression of vascular endothelial growth factor and matrix metalloproteinases in CRC cell lines. In recent years, signaling molecules of the insulin-like growth fac