荧光碳点及其在生物医药领域应用的研究进展fluorescent-药学学报.pdfVIP

1258 药学学报 Acta Pharmaceutica Sinica 20 14, 49 (9): 1258 1266 荧光碳点及其在生物医药领域应用的研究进展 1 2 1 1 1* 爽 , 高会乐 , 沈 顺 , 王纬亮 , 钱 隽 (1. 复旦大学, 智能化递药教育部重点实验室, 上海 201203; 2. 四川大学华西药学院, 药物靶向和药物递释系统教育部重点实验室, 四川 成都 61004 1) 摘要: 荧光碳点是一种新型的碳纳米材料, 与传统荧光探针相比具有光稳定性好、光不闪烁、不漂白等优点; 与半导体量子点相比, 具有生物相容性好、毒性小、表面易修饰等特点, 是具有良好发展前景的光学影像探针。 本文综述了荧光碳点的 本结构、碳源材料、制备方法、发光机制以及在生物医药领域的应用进展, 同时分析 讨论了荧光碳点在未来发展中需要解决的主要问题和研究方向。 关键词: 荧光碳点; 本结构; 碳源材料; 制备方法; 发光机制; 生物医药应用 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 14) 09- 1258-09 Fluorescent carbon dots and the application in biomedicine 1 2 1 1 1* ZHANG Shuang , GAO Hui-le , SHEN Shun , WANG Wei-liang , QIAN Jun (1. Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China; 2. Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, China ) Abstract : As a new type of carbon nanomaterials, fluorescent carbon dots (fluorescent CDs) have many advantages when compared with the traditional fluorescent probes . They are photoluminescence stable and resistance to photo bleaching. Moreover, they are excellent in biocompatibility, low-toxic and easy to modify. All these above make them a promising optical image material as a probe in optical image. This article reviews structure, the common carbon sources, the preparation methods, and the light-emitting principles of the carbon do