纳米载药系统防治龋病和牙周病的研究进展-华西口腔医学杂志.pdfVIP

35 1 2017  2 华西口腔医学杂志 第 卷 第 期 年 月 •04• West China Journal of Stomatology Vol.35 No.1 Feb. 2017 纳米载药系统防治龋病和牙周病的研究进展 江娅玲 冯明业 程磊 口腔疾病研究国家重点实验室 华西口腔医院牙体牙髓病科（四川大学），成都610041 [摘要] 龋病和牙周病是严重危害口腔健康的常见慢性感染性疾病，菌斑生物膜中的细菌是其始动因子。由于口腔 独特的生理、解剖等特点，化学药物作为牙菌斑控制方法之一在口腔应用中面临巨大挑战。纳米载药系统是运用纳 米技术而产生的一系列粒径在纳米级的新型微小载药系统，具有靶向性、缓释性、生物降解等显著优点，在龋病和 牙周病的防治中具有很多优势。本文就近年来纳米载药系统防治龋病和牙周病的研究进展作一综述。 [关键词] 纳米载药系统； 龋病； 牙周病； 牙菌斑； 纳米粒子 [中图分类号] R 78 [文献标志码] A [doi] 10.7518/hxkq.2017.01.017 Research progress on a nanodrug delivery system for prevention and control of dental caries and periodontal diseases Jiang Yaling, Feng Mingye, Cheng Lei. (State Key Laboratory of Oral Diseases, Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 6004, China) Supported by: The International Science and Technology Cooperation Program of China (204DFE3080); The Youth Grant of the Science and Technology Department of Sichuan Province, China (204JQ0033). Correspondence: Cheng Lei, E-mail: chengleidentist@63.com. [Abstract] Dental caries and periodontal diseases are common chronic infectious diseases that cause serious damage to oral health. Bacteria is the primary factor leading to such conditions. As a dental plaque control method, chemotherapeutic agents face serious challenges in dental care because of the specific physiological and anatomical characteristics of the oral cavity. Nanodrug delivery system is a series of new drug delivery systems at nanoscale, and it can target cells, promote sustained- release effects, and enhance biodegradation. This review focuses on research progress on nanodrug delivery systems for pre- vention and control of dental car