维生素D在自闭症中作用的研究进展.pdf

International Journal of Psychiatry and Neurology 国际神经精神科学杂志, 2014, 3, 21-27 Published Online November 2014 in Hans. /journal/ijpn /10.12677/ijpn.2014.34004 Role of Vitamin D in Autism Feiyong Jia, Ling Shan, Junyan Feng, Bing Wang, Honghua Li, Lin Du* Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun * Email: 1015613@ th th st Received: Oct. 7 , 2014; revised: Oct. 28 , 2014; accepted: Oct. 31 , 2014 Copyright © 2014 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract Autism is characterized by abnormal immunology, altered oxidative stress and even genetic ab- normality in addition to behavioral problems. Vitamin D deficiency is ubiquity in children with autism. Vitamin D plays a role in regulating immune, up-regulating glutathione, and controlling genome in addition to traditional action on calcium and phosphate regulation. We recently re- ported that vitamin D supplementation could improve the behavioral manifestations in autistic child, which illustrated that vitamin D was involved in the pathogenesis of autism. Herein we summarize the research progress of the role of vitamin D in autism. Keywords Autism, Vitamin D, Immunologic Regulation, Oxidative Stress, Genomic Stability 维生素D在自闭症中作用的研究进展 贾飞勇，单 玲，冯俊燕，王 冰，李洪华，杜 琳* 吉林大学，第一医院小儿神经康复科，长春 * Email: 1015613@ 收稿日期：2014年10月7 日；修回日期：2014年10月28 日；录用日期：2014年10月31 日 摘 要 自闭症临床表现为行为障碍，存在着免疫异常、氧化应激改变甚至基因异常。自闭症患儿普遍存在着维 *通讯作者。