持续病毒学应答对HCV感染相关原发性肝癌发生的影响.PDFVIP

·306· 传染病信息  2017年10月30日  第30卷  第5期  Infect Dis Info, Vol. 30, No. 5, October 30, 2017 ·综　　述· 持续病毒学应答 对HCV 感染相关原发性肝癌发生的影响 刘佳梁，纪　冬，陈国凤     [摘要]　HCV 感染是世界范围内慢性肝病的主要原因之一，且HCV 感染也是肝细胞癌发生的重要原因。以干扰素或 20 HCV 聚乙二醇干扰素为基础的抗病毒治疗在过去 余年间使大量 感染患者达到了清除病毒的治疗目的，即持续病毒学应答。 近年来随着直接抗病毒药的应用，患者中持续病毒学应答的比例得到了进一步提高，且因直接抗病毒药较低的不良反应率使 得更多患者能够得到治疗。本文对慢性HCV 感染者应用不同的抗病毒治疗方案获得持续病毒学应答后对原发性肝癌的发生 率的影响进行综述。     [关键词]　丙型肝炎病毒；肝细胞癌；干扰素；直接抗病毒药物；持续病毒学应答     [中国图书资料分类号]　R735.7　　　　[文献标志码]　A　　　　[文章编号]  1007-8134(2017)05-0306-05　    　　DOI:10.3969/j.issn.1007-8134.2017.05.015 Sustained virological response to the occurrence of hepatitis C virus infection related hepatocellular carcinoma * LIU Jia-liang, JI Dong, CHEN Guo-feng Liver Cirrhosis Center Department 2, Peking University 302 Clinical Medical School, 100039, China *Corresponding author, E-mail: guofengchen302@163.com 　　[Abstract]　Hepatitis C virus infection is one of the main causes of chronic liver diseases in the world and is an important reason for the development of hepatocellular carcinoma. Interferon or pegylated interferon based antiviral therapy has eradicated the virus in a huge amount of hepatitis C infected patients, which has been known as sustained virological response for two decades. With the use of direct-acting antivirals, a further increase has been seen in the percentage of sustained virological response. In addition, due to low rate of side effects, direct-acting antivirals have been applied in more patients. This study reviewes the influence of sustained virological response to the occurrence of hepatocellular carcinoma after chronic hepatitis C virus infected patients who