浙江大学医学免疫学经典课件免疫、B细胞.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Antigen-activated B cells differentiate into centroblasts that undergo clonal expansion in the dark zone of the germinal centre. During proliferation, the process of somatic hypermutation (SHM) introduces base-pair changes into the V(D)J region of the rearranged genes encoding the immunoglobulin variable region (IgV) of the heavy chain and light chain; some of these base-pair mutations lead to a change in the amino-acid sequence. Centroblasts then differentiate into centrocytes and move to the light zone, where the modifie