毕业论文--益髓生血颗粒治疗β-地中海贫血患者自身对照比较研究.docVIP

益髓生血颗粒治疗β-地中海贫血患者自身对照比较研究 作者：吴志奎,张新华,刘咏梅,李敏,陈玉英 吕鑫霞,柴立民,王文娟,王荣新,黄有文,刘文军,朱欲英 【摘要】 目的 观察补肾益髓法的代表方益髓生血颗粒治疗β-地中海贫血临床效果。方法 以高发区患者为观察对象,采用自身对照方法,30例重型、中间型β-地中海贫血患者先口服安慰剂再口服益髓生血颗粒,疗程均为3个月。观察服药前后患者临床症状、中医证候变化,并做血液指标血红蛋白(Hb)、红细胞(RBC)、胎儿血红蛋白(Ret)、网织红细胞(HbF)动态检测；中医临床证候表现按评分量表观察,记录不良反应。结果 患者自服安慰剂1个月至疗程结束,主要疗效性指标Hb、RBC均无升高,Hb在口服安慰剂第1个月有明显降低(Plt;0.05),而改服益髓生血颗粒自第1个月起至疗程结束患者Hb、RBC与服安慰剂第3个月比均有非常明显提高(Plt;0.001)；中医临床证候量表统计分析显示：口服安慰剂3个月后,患者临床中医证状无任何改善；经益髓生血颗粒治疗3个月后,患者除“面色萎黄”一项无明显改善外,“头晕目眩”、“心悸”、“气短”、“食少纳呆”、“倦怠乏力”等症状均有明显改善(Plt;0.05)；无任何不良反应。结论 患者服安慰剂后改服益髓生血颗粒3个月后,血液指标Hb、RBC、Ret、HbF与服安慰剂第3个月比均有非常明显提高。两个阶段β-地中海贫血患者疗效比较有非常显著性差异。 【关键词】 益髓生血颗粒；自身对照；β-地中海贫血 　　Abstract：Objective To study the clinical effect of compound Yisui Shengxue Keli (YSSXKL) on treating β-thalassemia. Methods By using self-control study method, 30 cases of major and intermediate β-thalassemia had been first treated with placebo for three months, then were treated with YSSXKL in the followed three months in Guangxi province, the high incidence area of the disease. The clinical symptoms, traditional Chinese medicine symptoms and dynamic changes of the blood levels of Hb, RBC, Ret and HbF were observed before and after each treatment. The CRF tables were filled in according to the traditional Chinese medicine symptoms of the patients and the side effects recorded. Results During period of placebo treatment, the main curtive effective indexes Hb and RBC were not obviously raised, while the RBC levels were inversely degraded after the first month of taking placebo orally (Plt;0.05). But from the first to the third month within course of YSSXKL treatment, both Hb and RBC levels were obviously higher than that of the third month of placebo treatment (Plt;0.001). Traditional Chinese symptoms CRF analysis revealed that the patients’ traditional Chinese symptoms had no obvious improvement after the three months treatment with placebo treatment. But in the following three months with YSSXKL treatment, the traditional Chinese s