乙型肝炎免疫球蛋白阻断乙型肝炎病毒母婴传播的临床分析.docVIP

精品论文 参考文献 乙型肝炎免疫球蛋白阻断乙型肝炎病毒母婴传播的临床分析 王和平 　　(四川省绵阳市平武县疾病预防控制中心 622550) 　　【摘要】目的 分析孕期注射HBIG及新生儿HBIG联合乙肝疫苗对乙肝病毒母婴阻断的临床效果。方法 对100例乙肝病毒携带者孕妇在妊娠28、32、36周注射乙肝免疫球蛋白(HBIG)200IU,新生儿出生后12h内注射乙肝免疫球蛋白(HBIG)100IU,加乙肝疫苗(10mu;g),出生后第4周注射乙肝免疫球蛋白(HBIG)100IU,并自满月按照1、2、7的程序全程接种乙肝疫苗(5mu;g),出生后第8个月取静脉血测乙肝两对半结果检测100例婴儿仅2例HBsAg阳性,婴儿获得保护率97.8%,100例中有94例获得保护性抗体HBsAb,免疫成功率达94%结论联合免疫有助于减少母婴垂直传播,提高婴儿保护率和免疫成功率 　　【关键词】乙型肝炎 母婴垂直传播 联合免疫 　　【中图分类号】R512.61+2 【文献标识码】A 【文章编号】2095-1752（2014）15-0102-02 　　Clinical analysis of mother to child transmission of hepatitis B virus hepatitis B immune globulin blockade 　　Wang he ping Sichuan Province Mianyang city Pingwu County Center for disease prevention and control 622550 　　【Abstract】 ObjectiveAnalysis of the clinical effect of pregnancy and neonatal injection of HBIG HBIG combined with hepatitis B vaccine against hepatitis B virus maternal and child blockMethodIn 100 cases of hepatitis B virus carriers of pregnant women in 28, 32 and 36 weeks of injection of hepatitis B immunoglobulin (HBIG) 200IU, injection of hepatitis B immunoglobulin after the birth of 12h (HBIG) 100IU, and hepatitis B vaccine (10 mu; g), fourth weeks of injection of hepatitis B immunoglobulin (HBIG) 100IU after birth, and since the full moon in 1, 2 and 7 of the whole procedure of inoculation of hepatitis B vaccine (5 mu; g), eighth months after the birth of the venous blood of two semi hepatitis B testingResultDetection of 100 cases of infants are HBsAg positive in 2 cases, babies get the protection rate was 97.8%, 100 cases in 94 cases of acquired protective antibody HBsAb, immune successful rate was 94%ConclusionCombined with immune helps to reduce vertical transmission, improve the infant protection rate and immune successful rate 　　【Key words】hepatitis B vertical transmission combined immunization 　　胎儿宫内感染HBV,不仅易形成以后慢性携带状态,而且是肝硬化和肝癌的高危因素。宫内感染难以阻断,是形成慢性乙肝的主要途径和原因。 阻断HBV母婴传播是控制乙肝流行及预防HBV相关肝病的关键[1]我院自2010年3月-2013年12月对绵阳市平武县