冠心病患者血钾水平与冠状动脉病变严重程度的关系.docVIP

精品论文 参考文献 冠心病患者血钾水平与冠状动脉病变严重程度的关系 （1.吉林省延边大学附属医院麻醉科 吉林 延吉 133000；2.吉林省延边大学附属医院中心实验室 吉林 延吉 133000） 【摘 要】目的：探讨冠心病患者血钾水平的高低与冠状动脉病变严重程度的相关性。方法：对799例冠脉造影患者的血钾水平进行测定，采用Gensini评分方法评价冠状动脉严重程度。结果：与对照组相比，le;20分组、21-40分组、41-100分组和＞100分组的血钾水平明显升高，有统计学差异（均 P＜0.05）；le;20分组、21-40分组和41-100分组之间，无统计学差异(P＞0.05)；100分以上组的血钾浓度高于41-100分组，有统计学差异(P＜0.05)。与对照组相比，血钾浓度在冠心病患者的不同病变范围即单支病变、双支病变、三支病变中均增高(均 P＜0.05)，但增高的程度与病变范围无明显关系(P＞0.05)。结论：本研究是第一次阐述了血钾水平随着冠状动脉病变严重程度增加而增高。 【关键词】冠心病；血钾；冠状动脉病变 【中图分类号】R541.4 【文献标识码】A 【文章编号】1004-6194（2015）02-0363-02 【Abstract】Objective: To investigate the relation between serum potassium levels and the severity of coronary artery lesions in coronary artery disease (CAD). Method: A total of 799 patients who underwent coronary angiography were selected. Serum potassium levels were measured, and the Gensini scores were calculated. The Gensini scoring system was used to evaluate the severity of coronary artery lesions in CAD. Results: The levels of serum potassium in the#61603;20, 21ndash;40, 41ndash;100, andgt;100groups were significantly higher than the level in the normal control group(all Plt;0.05); the 20, 21ndash;40, and 41ndash;100 groups showed no significant difference(Pgt;0.05); and the gt;100group showed significantly higher values than the 41ndash;100 group(Plt;0.05). In addition, the levels of serum potassium in the single-vessel, dual-vessel, and multiple-vessel groups were significantly higher than that in the normal control group(all Plt;0.05). Conclusion: This is the first report to suggest that the levels of serum potassium increase with the severity of coronary artery lesions. 【Key words】Coronary artery disease; Serum potassium; Coronary artery lesion 随着我国人民生活水平的提高，社会压力增加，体力活动减少，高脂肪饮食增多，再加上人口老龄化，每年冠心病的死亡人数和发病率仍呈持续上升趋势[1,2,3],严重威胁着我国人民的生命健康。冠心病是由冠状动脉血管管腔狭窄或阻塞引起的心肌缺血缺氧或心肌坏死的心脏病。 近年来，不少研究证明血清钾离子浓度（＜10mmol/L）增高可诱导小动脉平滑肌细胞的松弛并促进血管扩张[4,5]，并且高钾饮食在维持正常血压，预防冠状动脉粥样硬化起到一定的作用[6,7]。但人体内的血钾浓度与冠心病病变严重程度的相关性的研究较少。为探讨冠心病患者血钾水平