骨髓干细胞移植治疗运动神经元病的近期效果：72例疗效分析.docVIP

骨髓干细胞移植治疗运动神经元病的近期效果：72例疗效分析 中国临床康复第9卷笤9期2005—03—07出版 ChineseJournalofClinicalRehabilitation.March72005Sb1.9,09 骨髓干细胞移植治疗运动神经元病的近期效果:72例疗效分析 龚启明,颜永红,李岩松,刁士元,郭海涛,仇靖,黄丹凤,王敏,付晓东 ? 基础研究? 龚启明,颜永红,李岩松,刁士元,郭海涛,仇靖,黄丹凤,王敏,付晓 东,解放军第四六三医院神经内科,辽宁省沈阳市110042 龚启明,男,1950年生,湖南省南县人,汉族,1970年中国医科大学毕 业,学士,主任医师,主要从事缺血性脑血管病的介入治疗以及骨髓干 细胞移植治疗运动神经元病的研究.liyansongs@hotmailCOIII 电/g:+86—24中图分类号:R74文献标识码:A文章编号:1671—5926(2005)09—0040—02 收稿日期:2004—12—14修回日期:2005—01—14(15/SM/YW) Short.temeffectoftransplantationofmarrowstemcellon motorneurondisease:analysisoftherapeuticeffectin72pa. tientsGongOi—mngYonYong—hong,LiYon—songDiaoShi—yuanGuo Hal—tooOiuJing,HuongDon—feng,WangMinFuXiao—dong GongOi—ming,YonYong—hongLiYon—songDiooShi—yuonGuoHai—tao OiuJing,HuongDon—fengWangMinFuXiao—dong,DepartmentofNeu— rology,the463HospitalofChinesePLA,Shenyang110042,Liaoning Province,China Correspondenceto:GongOi—ming.Chiefphysician,DepartmentofNeurol— ogy,the463HospitalofChinesePLA,Shenyang110042,Liaoning ProvinceChinaliyansongs@hotmail.COIII Received:2004—12—14Accepted:2005—01—14 Abstract AIM:Toobserveshort—termeffeetofautograftofmarrowstemcells(MSCs) onthetreatmentofmotorneurondisease(MND).andstudytheroleinim一, provingthefunction. METH0DS:Totally72patientswhodiagnosedashavingMNDintheDe— partmentofNeurology,the463HospitalofChinesePLA,fromFebruaryto October2004weretreatedwiththeautograftofMSCs.AUpatientsweregiven somedrugsthatnurtureaneuronsintheperioperativeperiod.Theeffective standardswerewhetherthemusculartensionwasdecreased,whetherthe slurredspeech,dysphagiaandthedifficultyinraisingtheheadwereim— proved.whetherthetimesoffasciculationweredecreasedandwhetherthe mvodvnamiawasincreased.Ifanyoftheabovesymptomsbecameremissive, itwouldbeconsideredtobeeffective. RESULTS:Atiertheoperation.thefivesymptomsintwopatientswereall relieved;anyfoursymptomsin6patients,anythreesymptomsin20pa— tients.anytwosymptomsin28patientsandanyonesymptomin10patients wererelieved;thefivesymptomsin6patientswerenotrelieved.Ifanyofthe fivesy