三种麻醉方法在巴马小型猪失血性休克试验中的-中国试验动物学报.docVIP

研究报告 三种麻醉方法在巴马小型猪失血性休克实验中的麻醉效果比较 陈克研，刁玉刚，周锦，金强，张铁铮 （沈阳军区总医院麻醉科, 沈阳 110016） 【摘要】 目的 比较3种麻醉方法在巴马小型猪失血性休克（HS）实验中的麻醉效果，适巴马麻醉的最佳方案。方法 巴马小型猪24头，随机分为氯胺酮肌注射组(A组)，异丙酚静脉注射组(B组)，异丙酚静脉与七氟烷吸入复合麻醉组(C组)，每组8头。分别于麻醉前(T0)、诱导后(T1)、置管后(T2)、HS即刻(T3)、HS后30 min(T4)、复苏时(T5)、复苏后30 min(T6)及实验结束拔管后10 min (T7)，观察并记录各组猪的心率( HR)、平均动脉压( MAP)、鼻温( NT)、pH值及血氧饱和度（SPO2）等指标，同时记录麻醉诱导时间，恢复自主呼吸的时间，术中追加麻药例数，术后不良反应例数。结果 三组实验猪实验前身长、体重、血红蛋白量及放血量等一般情况比较无显著性差异（P0.05）；A组术中需多次给药并有躁动现象，术后有呕吐等不良反应；B组麻醉比较平稳，但在术中仍有躁动现象且需补加麻药；C组麻醉效果最佳，诱导期短，术中安全，恢复自主呼吸的时间短，术后无不良反应。结论 静吸复合麻醉，诱导时间短，麻醉效果好，术中平稳安全，术后苏醒快，适巴马手术麻醉。 【关键词】：巴马小型猪；失血性休克；氯胺酮；异丙酚；七氟烷 【中图分类号】R33【文献标识码】A【文章编号】1671-7856（201）-0000-00 Doi:10.3969/j.issn.1671-7856.2013.010.000 Comparison of the anesthetic effects of three anesthetic methods in experiments with Bama minipig models of hemorrhagic shock CHEN Ke-yan, DIAO Yu-gang, Zhou Jin, JIN Qiang, ZHANG Tie-zheng (Department of Anesthesiology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China) 【Abstract】 Objective ompare the anesthetic effects of three anesthetic methods on experiments with Bama minipig models of uncontrolled hemorrhagic shock (HS) and to develop an optimal anesthetic method. Methods Twenty-four male Bama minipigs were divided into three groups: Group A with intramuscular injection of Ketamine, group B with intravenous injection of Propofols, and group C with intravenous administration of propofol combined with sevoflurane inhalation, 8 pigs in each group. The heart rate (HR), mean arterial pressure (MAP), nose temperature (NT), pH value and blood oxygen saturation (SPO2) of the pigs at different time points including pre-anesthesia preparation (T0), after induction (T1), after catheterization (T2), immediately after HS (T3), 30 min after HS (T4), resuscitation (T5), 30 min after resuscitation (T6) and after extubation (7). The results of anesthesia, induction time, recovery time to spontaneous breathing, the number of cases of additional intraoperative anesthesia and the occ