2种调强放疗技术联合紫杉醇脂质体同步治疗ⅡB-ⅢB期宫颈癌的临床疗效比较.docVIP

2种调强放疗技术联合紫杉醇脂质体同步治疗ⅡB-ⅢB期宫颈癌的临床疗效比较 金艳霞 张晓兰 宋静 青海大学附属医院肿瘤妇科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 探讨适形调强放疗 (IMRT) 和容积旋转调强放疗 (VMAT) 2种调强放疗技术联合紫杉醇脂质体同步治疗ⅡB-ⅢB期宫颈癌的临床疗效和安全性差异。方法 选取青海大学附属医院2014年5月-2016年5月收治ⅡB-ⅢB期宫颈癌患者80例。以随机数字表法分为A组和B组, 每组40例, 分别在紫杉醇脂质体化疗基础上同步采用IMRT和VMAT辅助治疗;比较两组患者近期疗效、中位总生存时间 (OS) 、中位无进展生存时间 (PFS) 、中位远处转移时间 (DMR) 、中位局部复发时间 (LRR) 、治疗前后卡氏评分 (KPS) 及药物毒副作用发生率等。结果 两组患者近期疗效比较, 差异无统计学意义 (P0.05) ;两组患者中位OS、PFS、DMR及LRR时间比较, 差异无统计学意义 (P0.05) ;A、B组患者治疗后KPS评分与治疗前比较, 差异有统计学意义 (P0.05) , B组患者治疗后KPS评分高于A组;两组患者放射性直肠炎、放射性膀胱炎、消化道反应及肝功能损伤发生率比较, 差异无统计学意义 (P0.05) ;B组患者骨髓抑制发生率与A组比较, 差异有统计学意义 (P0.05) , B组低于A组。结论 IMRT和VMAT分别联合紫杉醇脂质体同步治疗ⅡB-ⅢB期宫颈癌在控制疾病进展、延长生存时间及降低转移复发风险方面效果接近;但VMAT方案可有效降低骨髓抑制发生风险, 提高日常生活质量。 关键词： 适形调强放疗; 容积旋转调强放疗; 紫杉醇脂质体; 宫颈癌; 疗效; 安全性; 收稿日期：2016-12-22 基金：青海省卫生和计划生育委员会卫生计生科研指导性计划课题 (No:Y2014-08) Clinical comparative study of two kinds of intensity-modulated radiotherapy regimens combined with paclitaxel liposome in treatment of cervical cancer in stage Ⅱ B and Ⅲ B Yan-xia Jin Xiao-lan Zhang Jing Song Department of Gynecologic Tumors, Affiliated Hospital of Qinghai University; Abstract： Objective To investigate clinical effect and safety differences of intensity-modulated radiotherapy (IMRT) and volume-modulated arc therapy (VMAT) combined with paclitaxel liposome in the treatment of cervical cancer in stage Ⅱ B and Ⅲ B. Methods Eighty patients with cervical cancer of stage Ⅱ B and Ⅲ B treated in our hospital from May 2014 to May 2016 were chosen and randomly divided into two groups including group A (40 patients) with IMRT and group B (40 patients) with VMAT on the basis of paclitaxel liposome. The short-term clinical efficacy, the median time of overall survival (OS) , progression free survival (PFS) , distant metastasis (DM) and local recurrence (LR) , the KPS scores before and after treatment and the incidences of drug side effects were compared between both groups. Results There was no significant diffe