表柔比星联合奥沙利铂及氟尿嘧啶的化疗方案提高局部进展期胃癌根治性手术机会的研究.docVIP

表柔比星联合奥沙利铂及氟尿嘧啶的化疗方案提高局部进展期胃癌根治性手术机会的研究 刘晓文 龙子雯 蔡宏 王亚农 复旦大学附属肿瘤医院胃外科,复旦大学上海医学院肿瘤学系 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 背景与目的:转化性化疗能使肿瘤降期, 提高胃癌根治性手术的切除率, 改善胃癌患者的预后。本研究旨在探讨EOF方案是否可以提高局部晚期胃癌根治性手术切除率, 同时评价转化性化疗的安全性和耐受性。方法:30例经病理证实为胃癌的患者, 影像学评估为潜在可根治的局部进展期胃癌入组。采用EOF方案进行治疗, 具体为奥沙利铂130 mg/m2, 静脉注射 (2 h) , 第1天;表柔比星50 mg/m2, 静脉注射 (2 h) , 第1天;氟尿嘧啶2 400 mg/m2, 静脉注射 (48 h) , 每3周重复1次, 共行24个周期。化疗结束后进行临床疗效及不良反应的评估。结果:30例局部进展期胃癌患者接受了EOF方案的化疗, 完全缓解 (complete response, CR) 为3.3% (1/30) , 部分缓解 (partial response, PR) 为26.7% (8/30) , 疾病稳定 (stable disease, SD) 为46.7% (14/30) , 疾病进展 (progressive disease, PD) 为23.3% (7/30) , 临床总有效率 (CR+PR) 为30% (9/30) 。66.7% (20/30) 的患者行手术切除, 其中46.7% (14/30) 获得根治性切除, 20% (6/30) 行姑息性手术。主要的化疗不良反应为白细胞减少53.3% (16/30) , 中性粒细胞减少53.3% (16/30) , 食欲减退43.3% (13/30) , 无化疗相关死亡。结论:EOF方案在局部进展期胃癌的治疗中是安全有效且耐受良好的方案。 关键词： 局部晚期胃癌; 转化性化疗; 奥沙利铂; 表柔比星; 氟尿嘧啶; 作者简介：王亚农 E-mail:wangyn1111@ 收稿日期：2017-05-30 Preoperative chemotherapy using the modified EOF regimen in patients with locally advanced gastric cancer: to increase the chance of radical surgery L IU Xiaowen LONG Ziwen CAI Hong WANG Yanong Department of Gastric Surgery, Fudan University Shanghai Cancer Center;Department of Oncology, Shanghai Medical College, Fudan University; Abstract： Background and Purpose: This study aimed to evaluate the efficacy and toxicity of chemotherapy using the modified EOF (oxaliplatin, epirubicin, calcium folinate, 5-fluorouracil) regimen in patients with locally advanced gastric cancer. Methods: Thirty patients diagnosed with locally advanced gastric cancer were included into this clinical trial. All these patients received the chemotherapy of modified EOF regimen. This regimen consisted of oxaliplatin at 130 mg/m2 intravenously (2 h) on day 1, epirubicin at 50 mg/m2 intravenously (2 h) on day 1, 5-fluorouracil at 2 400 mg/m2 intravenously (48 h) . All patients received two to four cycles of chemotherapy. After completing the two cycles of