老年人血浆同型半胱氨酸水平和颈动脉粥样硬化关系的研究.docVIP

老年人血浆同型半胱氨酸水平和颈动脉粥样硬化关系的研究 聂颖 冯新恒 陈宝霞 邱文风 夏蓉晖 卢云涛 庄润涛 北京交通大学社区卫生服务中心内科 北京大学第三医院心内科卫生部心血管分子生物学与调节肽重点实验室分子心血管学教育部重点实验室 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 探讨老年人血浆同型半胱氨酸 (homocysteine, Hcy) 水平和颈动脉粥样硬化的关系。方法 选取2015年16月于北京交通大学社区卫生服务中心体检的766例老年人为研究对象, 将其按照血浆Hcy水平分为Hcy正常组 (555例) 和Hcy升高组 (211例) , 并行颈动脉超声检查。结果 Hcy升高组老年人血浆Hcy水平显著高于Hcy正常组[ (20.38±6.92) μmol/L︰ (11.40±2.02) μmol/L, P=0.000]。颈动脉有斑块578例, 狭窄47例。Hcy升高组老年人颈动脉内-中膜厚度 (intima-media thickness, IMT) 增厚及双侧均有斑块者均显著多于Hcy正常组 (59.7%︰50.3%, P=0.019;53.6%︰44.7%, P=0.040) ;老年男性IMT增厚和颈动脉狭窄比例均显著高于老年女性 (63.9%︰41.3%, P=0.000;8.7%︰3.5%, P=0.003) 。结论 颈动脉斑块在老年人中普遍存在, Hcy水平升高, 老年人颈动脉硬化程度更重;老年男性颈动脉硬化较老年女性更严重。 关键词： 老年; 同型半胱氨酸; 颈动脉; 动脉粥样硬化; 作者简介：陈宝霞 E-mail:sunny9739@163.com 收稿日期：2016-12-20 基金：北京交通大学基本科研基金自由申报项目 (016JB00040) Study of relation between elevated homocysteine and carotid atherosclerosis in elderly people NIE Ying FENG Xin-heng CHEN Bao-xia QIU Wen-feng XIA Rong-hui LU Yun-tao ZHUANG Run-tao Beijing Jiaotong University Community Health Center; Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptide, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education; Abstract： Objective To explore the relation between plasma homocysteine (Hcy) and carotid atherosclerosis in elderly people.Method 766 elderly people who took physical examination in Beijing Jiaotong University Community Health Center from January 2015 to June 2015 were prospectively investigated in this study, they were divided into normal group (n = 555) and elevated group (n = 211) according to their levels of plasma Hcy.Carotid artery ultrasounds were performed.Result The mean total plasma Hcy was statistically higher in elevated group than normal group [ (20.38±6.92) μmol/L ︰ (11.40±2.02) μmol/L, P = 0.000].Carotid plaques were detected in 578 individuals and stenosis were found in 47 individuals.Th