左甲状腺素钠治疗甲状腺功能减退症效果观察.docVIP

左甲状腺素钠治疗甲状腺功能减退症效果观察 武翔宇 曹世光 西安交通大学第二附属医院核医学科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 分析不同方案治疗甲状腺功能减退症 (甲减) 的效果及对多项临床指标和血液流变学的影响。方法 选择西安交通大学第二附属医院2012年5月—2015年9月收治的甲减患者121例, 按照治疗方法分为观察组63例和对照组58例。对照组给予甲状腺素片, 观察组在对照组基础上联合左甲状腺素钠片。对两组治疗前后的甲状腺激素、心肌酶谱指标、炎性标志物及血液流变学指数水平进行比较分析, 并观察两组的治疗效果、住院时间和不良反应情况。结果 观察组总有效率显著高于对照组, 住院时间短于对照组 (P<0.05) 。治疗后, 两组总甲状腺素、游离三碘甲腺原氨酸、游离甲状腺素和血红蛋白水平高于治疗前, 且观察组高于对照组 (P<0.05) 。治疗后, 两组促甲状腺激素、天冬氨酸转氨酶、乳酸脱氢酶、肌酸激酶、肌酸激酶同工酶、肿瘤坏死因子-α、白介素-6、超敏C反应蛋白、血浆黏度、红细胞变性指数及纤维蛋白原水平均低于治疗前, 且观察组低于对照组 (P<0.05) 。两组不良反应总发生率比较差异无统计学意义 (P>0.05) 。结论 甲状腺片联合左甲状腺素钠片治疗甲减能快速恢复甲状腺激素水平, 提高疗效, 缩短住院时间, 改善临床症状, 安全性高。 关键词： 甲状腺功能减退症; 左甲状腺素钠片; 甲状腺素片; 血液流变学; 收稿日期：2017-06-21 基金：陕西省科技厅研究发展计划项目 (2012K16-08-15) Effect Observation of Levothyroxine Sodium in Treatment of Patients with Hypothyroidism WU Xiang-yu CAO Shi-guang Department of Nuclear Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University; Abstract： Objective To analyze effectiveness of different plans in treatment of patients with hypothyroidism and the effects on clinical indexes and hemorheology.Methods A total of 121 patients with hypothyroidism admitted during May 2012 and September 2015 were divided into observation group (n=63) and control group (n=58) .Control group was treated with Thyroid Tablets, while observation group treated with Levothyroxine Sodium Tablets combined with Thyroid Tablets.In two groups, levels of thyroid hormone, myocardial zymogram indexes, inflammatory markers and hemorrheologic indexes were analyzed before and after treatment, and therapeutic effects, hospitalization time and incidence of adverse reactions were observed.Results In observation group, the total effective rate was significantly higher, while hospitalization time was significantly shorter than those in control group (P<0.05) .After treatment, levels of total thyroxine, free triiodothyronine, free thyroxine and hemoglobin were significantly higher than those before treatme