疏肝解郁胶囊治疗轻度抑郁症的临床疗效观察.docVIP

精品论文 参考文献 疏肝解郁胶囊治疗轻度抑郁症的临床疗效观察 施玉梅 孙红杰 郝翠杰 许小梅 冯实 　　（河北省荣军医院（保定） 071000） 　　【摘 要】目的：比较疏肝解郁胶囊与帕罗西汀治疗轻度抑郁症的疗效和安全性。方法：将146例门诊轻度抑郁患者随机分为2组，研究组给予疏肝解郁胶囊治疗，对照组给予帕罗西汀，疗程8周。采用汉密尔顿抑郁量表（HAMD）和治疗中出现的副反应量表（TESS）评定疗效及不良反应。结果：治疗8周末2组HAMD评分均明显下降（Plt;0.01），研究组与对照组无显著性差异（chi;2=29.71,Pgt;0.05）。结论：疏肝解郁胶囊治疗轻度抑郁症与帕罗西汀治疗轻度抑郁症疗效相当，不良反应较帕罗西汀轻微。 　　【关键词】疏肝解郁胶囊；帕罗西汀；轻度抑郁症 　　【中图分类号】R749.4 【文献标识码】B 【文章编号】1003-5028（2015）8-0713-01 　　The efficacy and safety of Shuganjieyu capsule in treatment of slight depression 　　SHI Yu-mei, SUN Hong-jie ,et al.Rongjun Hospital of Hebei Province,Baoding 071000,China 　　【Abstract】Objective To evaluate the efficacy and safety of Shuganjieyu capsule in treatment of slight depression. Methods 146 slight depressive patients symptoms were randomly divided into research group which received Shuganjieyu capsule and control group which received Paroxetine for 8 weeks.Curative effects were assessed using Hamilton depression scale(HAMD).Adverse reations were assessed with treatment emergent symptoms scale(TESS). Results The two groups showed significant score decreases on HAMD（Plt;0.01） , the scores of HAMD in the both groups were not different but the research groups showed faster score drop on HAMD and higher effective rate than control group. There were no significant differents.Conclusions There were no significant differents on efficacy between the Shuganjieyu capsule and Paroxetine。 Shuganjieyu capsule is more safe than Paroxetine in treatment of refractory depression. 　　【Key words】Shuganjieyu capsule ；Paroxetine；slight depression 　　有关专家推断美国和欧洲诸国抑郁障碍的时点患病率在12%～17%之间，终身患病率为20%左右 。大多数的抑郁症患者并未得到及时、有效的治疗。轻度抑郁症可导致人际关系疏远，家庭关系不和，严重影响正常的工作和生活，因为抑郁症患者经常对药物的不良反应比较敏感，临床上要求中药治疗的人日渐增多。本研究分别用疏肝解郁胶囊及帕罗西汀治疗轻度抑郁症，观察其疗效与不良反应，现将其报告如下。 　　1 对象和方法 　　1.1 研究对象 2012年01月到2014年12月我院门诊患者，入组标准：共146例，按入组先后顺序随机分为2组。研究组（疏肝解郁胶囊），符合ICD-10轻度抑郁发作的诊断标准，排除继发性抑郁；排除重度抑郁；排除严重器质性疾病及妊娠、哺乳期妇女； HAMDgt;17。入组共146例，随机分为2组：研究组73例，平均年龄（29.12plusmn;4.82）岁，对照组（28.61plusmn;4.26）岁，两组在性别、年龄上无显著差异（P