四氧化三铁微粒与碘化油混悬液栓塞兔肾动脉的试验研究.PDFVIP

·140 · 中国介 入影 像与治 疗学2005 年第 2 卷第 2 期 Chi n J I nterv I maging Ther ,2005 , Vol 2 , No 2 Transcather rabbit renal arterial embolization usi ng suspension from magnetic microspheres with lipiodol : experi mental study * GU Ya-l v , YUA N Shu- guang , YA N Dong , LUO Gan , HA N Zheng-li n , PU Cheng-rong , WA NG Ji a- pi ng ( De part ment of Radiol ogy , Second Af f iliate d Hos pital of Kunmi ng Medical Coll ege , Kunmi ng 650 10 1, China) ABSTRACT Obj ective To i nvesti gate t he e mbolic effectiveness and mechani s m of targeti ng e mbolizati on of the suspension fro m magneti c mi crospheres wit h li pi odol by transcat her renal arteri al e mbolization of rabbits ki dneys . Methods The sus- pendi ng ability of five size of magneti c microsphere which average di ameter was 50 , 100 , 150 , 200 , and 250 μm were eval u- ated by test of t heir falli ng speed and ti me i n li pi odol . Fifteen healt hy Ne w Zeal and rabbits were divi ded i nto t wo groups at rando m, 10 for the experi mental group e mbolized wit h the suspension of 250 μm magnetic mi cros pheres and li pi odol , 5 for t he control group only embolized wit h li piodol . Two groups experi mental results were based on abdo mi nal plai n fil m, renal arteri ography and hist opathologic study of t he e mbolized and une mbolized kidneys , heart , l ung , liver after sacrifi ce 3 days , 1, 2 , 4 , 6 , or 8 week after e mbolization . Results Five size of magnetic microsphere not only can be suspended i n li pi odol but keep s uspendi ng situati on for a rel ative l ong ti me . The average ti me when they fall 10 % i n li piodol were 120 , 85 , 60 , 45 , 30 mi n and the average falli ng speeds were 0 .32 , 0 .45