硼替佐米为主的化疗方案治疗58例多发性骨髓瘤患者的临床分析.docVIP

精品论文 参考文献 硼替佐米为主的化疗方案治疗58例多发性骨髓瘤患者的临床分析 咸阳市中心医院 陕西 咸阳 712000 摘要：目的：分析以硼替佐米为主的化疗方案治疗多发性骨髓瘤患者的临床疗效，为更加有效安全的治疗多发性骨髓瘤提供方案。方法：选取咸阳市中心医院2012年3月至2015年3月被诊断为多发性骨髓瘤患者58例，采用以硼替佐米为主，联合地塞米松、沙利度胺以及表柔比星的化疗方案进行治疗。分析记录患者治疗前后骨髓内浆细胞量、血清M蛋白量以及beta;2- 微球蛋白的变化情况。结果：结果显示在58例患者中48例是初治患者，10例为多次复发患者。其中初治患者治疗有效率81.25%；多次复发患者治疗有效率为70.00%。58例患者均采用硼替佐米为主的化疗，与治疗前比较，其骨髓内浆细胞量、血清 M 蛋白量以及 beta;2-微球蛋白的数值显著降低，差异具有统计学意义 (Plt;0.05)。结论：采用以硼替佐米为主的化疗方案治疗多发性骨髓瘤，在选用初治、复发及难治患者可以有效提高临床疗效，提高患者生存质量，与此同时，密切监测患者的不良反应也尤为重要。 关键词：硼替佐米；多发性骨髓瘤；沙利度胺；临床疗效 【中图分类号】R733.3【文献标识码】 A Clinical Analysis of 58 Cases of Patients with Multiple Myeloma Bortezomib Based Chemotherapy Zhang Guangying The central hospital of Xianyang City，Xianyang 712000 ,China Abstract: objective: to analysis is given priority to with boron for Mr M the clinical efficacy of chemotherapy for treatment of multiple myeloma patients, to provide more effective security in the treatment of multiple myeloma. Methods: selection of xianyang center hospital in March 2012 to March 2015 were diagnosed with 58 patients with multiple myeloma, use with boron for rice is given priority to, combined dexamethasone, Sally degrees of amine and epirubicin chemotherapy regimens for treatment. Analysis of patients before and after treatment in the amount of plasma cells in the bone marrow, M protein and serum beta 2 - microglobulin changes. Results: the results showed that in 58 patients with 48 cases is treated first patients, 10 cases of recurrence in patients with many times. The initial treatment in patients with effective rate was 81.25%; Many patients with recurrent treatment effective rate was 70.00%. Adopt boron for 58 patients with rice is given priority to chemotherapy, compared with before treatment, the plasma cells in bone marrow, serum M protein amount and the value of beta 2 - microglobulin significantly reduced, statistically significant difference (P lt; 0.05). Conclusion: use with boron for rice based chemotherapy regimen for multiple myeloma, govern