磁共振弥散张量成像在原发性青光眼视放射中的应用研究.docVIP

精品论文 参考文献 磁共振弥散张量成像在原发性青光眼视放射中的应用研究 张放 文雯2 朱文卿2 沙炎1（通讯作者）叶昕裴1 王申江1 　　1复旦大学附属眼耳鼻喉科医院放射科；2复旦大学附属眼耳鼻喉科医院眼科 　　摘要：目的：探讨磁共振弥散张量成像（diffusion tensor imaging，DTI）技术显示不同时期青光眼视放射神经变性的价值。方法：选择原发性青光眼早、晚期及正常对照组各15例行视觉通路DTI检查。分别测量左右两侧视放射的各向异性分数（fractional anisotropy，FA）、平均弥散率（mean diffusivity，MD）、平行扩散率（axial diffusivities，lambda;//）和垂直扩散率（radial diffusivities，lambda;perp;），使用SPSS16.0统计学软件分析病变组与对照组各参数之间的差异。结果：与正常对照组比较，早期青光眼患者视放射FA值、lambda;//值轻度降低，MD值轻度增高，差异无统计学意义（Pgt;0.05），lambda;perp;值显著升高（P=0.033）；晚期青光眼患者视放射FA值、lambda;//值显著降低（P=0.000，P=0.028），MD值、lambda;perp;值显著升高（P=0.043，P=0.000）。晚期青光眼较早期青光眼视放射FA值显著降低（P=0.000），lambda;perp;值显著升高（P=0.001），MD值升高，lambda;//值降低，差异无统计学意义（Pgt;0.05）。结论：DTI技术可以多参数显示不同时期青光眼视放射的神经变性，并能一定程度上反映病变严重程度，FA值和lambda;perp;值较MD值和lambda;//值更能敏感地反映视放射的损害。 　　关键词：原发性青光眼；扩散张量成像；视放射 　　[Abstract] Purpose：To study the value of MR diffusion tensor imaging（DTI）in evaluating the neurodegenerative changes of optic radiations in primary glaucoma patients. Methods：Fifteen early glaucoma patients，15 severe glaucoma patients，and 15 normal volunteers were enrolled．Conventional MRI and DTI in visual pathway were performed on all subjects using Siemens Verio 3T scanner. Fractional anisotropy（FA），mean diffusivity（MD），axial diffusivities（lambda;//）and radial diffusivities（lambda;perp;）were measured in optic radiation，and then the difference was compared between patients group and control group using the statistical software of SPSS 16.0. Results：Compared with control group，the values of FA and lambda;// in early glaucoma were lightly decreased，and that of MD were lightly increased，which was no statistical difference（Pgt;0.05）. While the value of lambda;perp; was significantly higher than that of in control group（P=0.033）. In severe glaucoma，the values of FA and lambda;// were decreased obviously（P=0.000，P=0.028）and the values of MD and lambda;perp;were increased significantly（P=0.043，P=0.000）than those of in control group. Compared with early glaucoma，the value of FA in severe gla