芪参益气滴丸对缺血性心肌病患者BNP和心功能的影响.docVIP

精品论文 参考文献 芪参益气滴丸对缺血性心肌病患者BNP和心功能的影响 曹丽君1 冯春光2 　　（1江苏省新沂市中医院心内科 221400） 　　（2江苏省徐州市中心医院心内科 221009） 　　【摘要】目的 评价芪参益气滴丸对缺血性心肌病患者的临床疗效及对6min步行距离、血浆脑钠素(BNP)和左室舒张末期直径（LVEDD）、左室射血分数（LVEF）值的影响。方法 缺血性心肌病患者57例，在常规药物治疗基础上按是否应用芪参益气滴丸分成分为A组（芪参益气滴丸应用组，28例），B组（对照组，29例）。结果 入院第一天两组6min步行距离、BNP和LVEDD、LVEF值差异无统计学意义。入院后第90日：A组6min步行距离明显高于B组Plt;0.05；A组BNP值明显低于B组Plt;0.05；A组LVEF值明显高于B组Plt;0.05；A组LVEDD值明显低于B组Plt;0.05。A组、B组治疗前后组内比较上述指标，治疗90天后明显优于治疗前。结论 在常规药物治疗基础上芪参益气滴丸能进一步降低缺血性心肌病患者BNP值和改善心功能指标。 　　【关键词】缺血性心肌病 芪参益气滴丸 　　【中图分类号】R285 【文献标识码】A 【文章编号】2095-1752（2013）34-0060-02 　　【Abstract】0bjectives To evaluate the curative effect of Qishenyiqi Dripping Pills in patients with ischemic cardiomyopathy on the 6-minute walk distance, the concentration of serum brain natriuretic peptide (BNP)and the values of left ventricular end-diastolic diameter(LVEDD) and left ventricular ejection fraction(LVEF).a Methods Forty seven patients with with ischemic cardiomyopathy were randomly divided into group A (treatment group：28 cases)and group B (control group：29 cases).Results On the first day of admission, there were no statistical difference between two groups on the values of 6-minute walk distance,the concentration of BNP, LVEDD and LVEF. On the 90th day of admission, the values of 6min walking distance in group A was more than that in group B,Plt;0.05;the concentration of BNP in group A were less than those in group B，Plt;0.05; the values of LVEF in group A were more than those in group B，Plt;0.05 ; the values of LVEDD in group A were less than those in group B，Plt;0.05. Those values in each group on the 90th day were obviously superior than on the first day of admission. Conclusions In the patients with with ischemic cardiomyopathy, based upon the routine medication, Qishenyiqi Dripping Pills can effectively improve the cardiac function. 　　【Key words】ischemic cardiomyopathy Qishenyiqi Dripping Pills 　　冠状动脉长期相对或绝对供血不足易引起心肌组织发生营养障碍和萎缩，以致纤维组织增生