血管紧张素转换酶基因多态性与替米沙坦降压疗效关系研究.docVIP

精品论文 参考文献 血管紧张素转换酶基因多态性与替米沙坦降压疗效关系研究 龚洪涛　杜凤和　陈步星通讯作者 首都医科大学附属北京天坛医院　北京　１０００５０ 　　【摘要】　目的探讨血管紧张素转换酶(ACE)基因的插入/缺失(I/D)多态性与替米沙坦降压疗效之间的关系.方法符合WHO/ISH 高血压诊断标准的轻中度高血压患者１４８例,服用替米沙坦单药治疗８周,在临床观察疗效的同时,应用聚合酶链反应(PCR)对患者ACE基因I/D多态性进行分析,同时测定空腹血糖、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL－C)及高密度脂蛋白胆固醇(HDL－C)等生物化学指标.结果ACEI/D各基因型在药物治疗后每一组患者的血压均有下降,每一组治疗前后SBP、DBP的差异均有显著统计学意义(P＜０．０５);而治疗前后收缩压、舒张压及降压幅度在各组之间无明显差异(P＞０．０５).结论ACEI/D基因多态性与替米沙坦降压疗效无相关性. 【关键词】　高血压;　血管紧张素转换酶;　基因多态性;　血管紧张素II１型受体拮抗剂AssociationBetweenPolymorphismofAngiotensinConvertingEnzymeGeneandpressure－lowingresponsetotelmisartantreatmentinHypertensionpatients　GONGHong－taoDUFeng －heCHEN Bu －xing 　(Departmentof Cardiology,Beijing Tiantan Hospital,CapitalUniversityof MedicalScience,Beijing１０００５０,China)【Abstract】　Objective:Toinvestigatewhethertheinsertion/deletion(I/D)polymorphismofangiotensinconvertingenzyme(ACE)geneareassociatedwithbloodpressureresponsetotelmisartaninhypertensivepatients．Methods:Afteratwo－weeksingle－blindplaceborun－inperiod,１４８patientswithmild－tomoderateprimaryhypertensionreceivedmonotherapywith８０mg/dayoftelmisartanandthenwerefollowedupforeightweeks．Theinsertion/deletion(I/D)polyＧmorphismofangiotensinconvertingenzyme(ACE)geneweredeterminedthroughPCRanalysis．Therelationshipbetweenthispolymorphismandchangesinbloodpressurewasobservedandevaluatedaftereightweekstreatment．Results:ThebloodpressureineachgroupofACEI/DgenotypedecreasedaftermedicaltreatＧment．Comparedtobloodpressurebeforetreatment,systolicbloodpressure(SBP)anddiastolicbloodpressure(DBP)ineachgroupaftertreatmenthadsignificantstatisticalsignificance(P ＜０．０５)．Andsystolicbloodpressure,diastolicpressurebeforeandaftertreatmentandpressure－lowingrangeineachgrouphavenoobviousdifference(P ＞０．０５)．Conclusions:WeconcludethatACEI/Disnotassociatedwithbloodpressureresponsetotelmisartantreatmentinhypertensivepatien【tKse．ywords】　Essentialhypertension;　Angiotensinconvertingenzyme;　Singlenucleotidepolymorphism;　AngiotensinIIreceptorblocker 【中图分类号】R５４４．１ 【文献标识码】A 　　【文章编号】１００８－６３１５(２０１５)