血糖波动对2型糖尿病患者脂肪细胞型脂肪酸结合蛋白的影响.docVIP

精品论文 参考文献 血糖波动对2型糖尿病患者脂肪细胞型脂肪酸结合蛋白的影响 赵蕾1 逄力男2 (通讯作者) 　　(1潍坊医学院硕士研究生 261041；2潍坊市人民医院内分泌科 261041) 　　【摘要】目的 研究血糖波动对2型糖尿病患者脂肪酸结合蛋白的影响。方法 2型糖尿病患者40例，健康者20例，测定空腹血糖、餐后2小时血糖、糖化血红蛋白、体重指数、血压，总胆固醇、甘油三酯、脂肪细胞型脂肪酸结合蛋白，按血糖波动将2型糖尿病患者分为A组（差值＜6mmol/L），B组（差值≧6mmol/L），比较各组脂肪细胞型脂肪酸结合蛋白水平。结果 血糖波动越大，脂肪细胞型脂肪酸结合蛋白浓度越高 结论2型糖尿病患者血糖波动与脂肪细胞型脂肪酸结合蛋白浓度相关，可作为评估2型糖尿病危险因素指标之一。 　　【关键词】 2型糖尿病 脂肪细胞型脂肪酸结合蛋白 血糖波动 胰岛素抵抗 　　【中图分类号】R587.2 【文献标识码】A 【文章编号】2095-1752（2014）20-0031-02 　　Relations between blood glucose fluctuations and adipocyte fatty acid binding protein in patients with type 2 diabetes ZHAOLei,PANGLi-nan.WeiFangMedicalUniversity[1],Department of Endocrinolocy,Weifang Peoplersquo;s Hospital[2], Shandong 261041,China. 　　【Abstract】 Objective To study the relationship between blood glucose fluctuations and adipocyte fatty acid binding protein in patients with type 2 diabetes. Methods 40 patients with type 2 diabetes and 20 healthy people, examine the fasting plasma glucose(FPG), 　　2-hour postprandial blood glucose(2hPG)，glycosylated hemoglobin(HbAlc)，body mass index(BMI), blood pressure(BP), cholesterol(TC)，triglyceride (TG), Adipocyte fatty acid binding protein(A-FABP).According to the blood glucose fluctuations ,we divided 40 patients with type 2 diabetes into 2 groups:A group(difference＜6mmol/L),B group(difference≧6mmol/L), and the A—FABP levels were compared between them． Results The larger the blood glucose fluctuations,the higher adipocyte fatty acid binding protein concentration. Conclusion The blood glucose fluctuations of the patient with type 2 diabetes is closely related with adipocyte fatty acid binding protein concentration,and may serve as a useful marker for the type 2 diabetes. 　　【Key words】Type 2 diabetes Adipocyte fatty acid binding protein Glucose fluctuation Insulin resistance 　　2型糖尿病是一个全球范围的健康问题。2010年全球约有2.85亿人口患有糖尿病，约占总人口的6.4%，而其中90-95%为2型糖尿病，预计到2030年被诊断出患有2型糖尿病的患者将超过3.5亿。脂肪细胞型脂肪酸结合蛋白（Adipocyte fatt