Gene-expression profiles in human nasal polyp tissues and identification of精选.pdfVIP

doi: 10.1111/j.1365-2222.2009.03229.x Clinical Experimental Allergy, 39, 972–981 ORIGINAL ARTICLE Asthma and Rhinitis c 2009 Blackwell Publishing Ltd Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma ,w w z ‰ z k k , T. Sekigawa , A. Tajima , T. Hasegawa , Y. Hasegawa , H. Inoue , Y. Sano , S. Matsune , Y. Kurono and I. Inoue Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan, wDivision of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, zDepartment of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan, ‰ Research Institute for Diseases of the Chest, Kyushu University Faculty of Medicine, Fukuoka, Japan, z Doai Memorial Hospital, Tokyo, Japan, kDepartment of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi, Japan Clinical Summary Background Aspirin-intolerant asthma (AIA) is a subtype of asthma induced by non-steroidal Experimental anti-inflammatory drugs and characterized by an aggressive mucosal inflammation of the Allergy lower airway (asthma) and the upper airways (rhinitis and nasal polyp). The lower airway lesion and the nasal polyp in AIA are postulated to have common pathogenic features