心肌肥厚的早期分子机制医学课英文教学教程.pptVIP

* * Early Molecular Mechanism Underlying Cardiac Hypertrophy Youyi Zhang Institute of Vascular Medicine Peking University Third Hospital 12 nm 电压依赖L型钙通道 Ca2+ Ca2+ LCC RyR SR 钙池 Pathological factors Hormones Neurotransmitters Cytokines Force Function maintenance Heart failure Ca2＋ Ca2＋ Early molecular mechanism underlying cardiac hypertrophy ? 1. Ca2+ transients triggered by comparable LCC currents are decreased in amplitude and slowed in heart failure 2. Compensated hypertrophy shows that the cellular aspects of E-C coupling appear to be normal The molecular details und