LTP好总结.docxVIP

谈到LTP不能不提到Donald Hebb以及他在1949年说过的一段话：``When one cell repeatedly assists in firing another, the axon of the first celldevelops synaptic knobs (or enlarges them if they already exist) in contactwith the soma of the second cell.”?``When an axon of cell A is near enough to excite a cell B and repeatedly orpersistently takes part in firing it, some growth process or metabolic?change takes place in one or both cells, such that A’s efficiency as oneof the cells firing B, is increased.”?这段话预言了学习记忆的机制——LTP的发现。1973 年，Bliss 等在海兔海马的单突触传入通路上给与短串强直刺激后，使突触后细胞的兴奋，突触后电位出现长达数天乃至数周的振幅增大，这种现象称之为长时程突触增强（LTP）。从此，LT