霍奇金淋巴瘤诊断与治疗医学课件.ppt精选.ppt

晚期（进展期）HL Ⅲ、Ⅳ期，巨块、B症状 ABVD仍为标准治疗,40%治疗失败 巨块病灶辅助放疗IFRT, 改善DFS BEACOPP（含辅助放疗）强度增大、疗效提高，5y OS 80%，副作用可耐受 * N Engl J Med 348;24,12, 2003 Standard and Increased-Dose BEACOPPChemotherapy Compared with COPP-ABVD for Advanced Hodgkin’s Disease * newly diagnosed HD, in unfavorable stage IIB or IIIA or stage IIIB or IV 219 hospitals and practices in Germany, Switzerland, Austria, and the Czech Republic Randomization was stratified RT: initial bulky disease (those at least 5 cm in diameter) received 30 Gy of irradiation , residual tumor received 40 Gy The outcome of t