(精编)【医学教学课件】Reproductive Physiology教学课件.pptVIP

Various sexual hormones changes in late follicular phase and ovulation Various sexual hormones changes in late luteal phase Mechanism of menstrual cycle induced by the changes in various sexual hormone * Endometrium Pregnancy and parturition1. Pregnancy Fertilization of the oocyte occurs within 24 hours of ovulation in the distal end of the oviduct. Fertilized egg completes second meiosis and divides repeatedly to form multicelled blastocyst. Blastocyst implants in uterine wall within 5 days of ovulation. After implantation, blastocyst secretes human chorionic gonadotropin (hCG, within 9 days of ovulation), which signals the corpus luteum to continue secreting progesterone and estradiol and is basis of the pregnancy test. Progesterone is produced from cholesterol by the placenta and estriol through the interaction of the placenta and fetal adrenal cortex and liver. Progesterone and estriol support development of the fetus as well as maternal breast development. The mechanism by which parturition is initiated is unclear but involves an interplay between progesterone, prostaglandins, and oxytocin that increase the frequency of uterine contraction. Effect of the theca and granulose cells of the ovary Granulosa Cells Theca Cells Cholesterol Cholesterol Pregnenolone Pregnenolone 17-Hydroxypregnenolone Dehydroepiandrosterone Androstenedione Testosterone Androstenedione Testosterone Estradiol - - - - Androstenedione Testosterone Estradiol The theca and granulose cells of the ovary interact to ensure adequate production of androgens (androstenedione, testosterone) and estradiol. Precondition of pregnancy is ovum must combine with sperm Precondition of pregnancy is ovum must combine with sperm to be zygote The process of zygote Formation受精卵的形成过程 Ovulation and fecundation排卵与受精 Growth of fetus (10 weeks) * Chapter 12Reproductive Physiology Wang Guoqing Department of Physiology, Medical School, Soochow University, Suzhou 215123, China E-mail:wangguoqing@suda.edu.