NF_B的信号通路与阻断策略.pdfVIP

　Chinese Journal of Pathophysiology 　2003, 19(6):849-855 ·849 · [] 　1000-4718(2003)06-0849-07 ·　· NF-κB＊ 邢飞跃, 　赵克森, 　姜　勇■ (, 510514) Signal transduction pathway and blocking strategies of NF-κB ING Fei-yue, ZHAO Ke-sen, JIANG Yong (Key Lab f or Shock and Microcirculation of PLA, F irst Military Medical University , Guangzhou 510515, China ) 　　【A Review】　NF-κB is thought of as a genetic switch to control expressions of many target genes and directly participates in pathogenesis of infection, inflammation, stress, immunoresponse, cellular apoptosis, toxic shock and tumor as well as cell-cycle regulation and cell differentiation.The overactivation of NF-κB is intimately involved in many human diseases.Various therapeutic strategies against NF-κB, to date, in- clude anti-inflammatory drugs, antioxidants, immunosuppressive agents, inhibitors of protease and protea- some, prostaglandings, nitric oxide, IL-10, microbial products, synthetic inhibitors, antisense oligonu- cleotides and decoy deoxyoligonucleotides.Studies are underway to develop NF-κB member-specific and cell type-specific drugs that can inhibit the activation of NF-κB only in target cells and that may become a novel way to treat the human diseases. 　　[] 　NF-Kappa B;;; 　　[KEY W RDS] 　　NF-κB;Signal transduction;Inflammation;Neoplasma 　　[] 　R363　　　　　[] 　A 　　κB(nuclear factor-kappa B, NF-κB) 、、、、、 p50/p65 、。 , NF-κB (in- ,NF-κB 、 hibitor kappa B, IκB)。 、、 [4-6] ,, TNF-α、IL-1、 , NF-κB 、C 、、 , 、、、、(lipopolysacchar- 。 [1-3] 1　NF-κB ide, LPS)、 。 NF-κB IκB / SenBaltimore (1986)NF-κB κB , κ κB ,。 (GGGACTTTCC), ,NF-κB 。NF-κB ,