博士生课程固有免疫模式识别.ppt

Conserved pathways in innate immunity in Drosophila and mammals. Examples chosen are, left, the induction of the antifungal gene drosomycin by binding of processed Spaetzle protein to the transmembrane receptor Toll and, right, activation of costimulatory protein genes by binding of a LPS-LBP-CD14 complex to a human Toll homolog, TLR4. DD, death domain; KD, kinase domain; LRR, leucine-rich domain; TIR, Toll/IL-1 receptor homology domain Negative regulation of Toll-like receptor 4 (TLR4) signaling. Proteins interfering with primary TLR signaling and/or acting at early times after TLR stimulati