济南生殖课件现代口服避孕药的非避孕应用－2014章节幻灯片.pptVIP

* 服用妈富隆后月经量会显著减少。 服用妈富隆，一些月经紊乱症状如经量过多、经期延长和痛经等症状都会在服药期间缓解或消失。 How OCs Improve Primary Dysmenorrhea Two mechanisms are probably involved in OC-induced reduction or relief of dysmenorrhea. First, ovulation suppression prevents progesterone-stimulated endometrial production of prostaglandin F2-?. Second, reduced endometrial growth leads to decreases in menstrual fluid volume and the release of smaller amounts of prostaglandin F2- ?. POSTED: August 29, 2001 REVIEWED: August 29, 2001 Escobar-Morreale HF. Lasuncion MA. Sancho J. Treatment of hirsutism with ethinyl estradiol-desogestrel contraceptive pills has beneficial effects on the lipid profile and improves insulin sensitivity. Fertility Sterility 2000; 74(4): 816-9 为了衡量Marvelon对于多毛症女性脂类以及胰岛素敏感性的副作用，16名多毛症女性接受了临床试验。样本在基准点和接受六次疗程后进行评估。服用Marvelon显著地增加了性激素结合球蛋白水平，增幅超过250%；并且显著地降低了多毛症和高雄性激素血症评分。从该研究中我们可以得出一个结论：Marvelon能有效地控制高雄性激素血症和多毛症，并且改善多毛症女性的异常代谢。 Bilotta P, Favilli S. Clinical evaluation of a monophasic ethinyl/desogestrel containing oral contraceptive. Arznei Forsch/Drug Res 1988; 38 (II): 932-4 如前所述，于意大利进行的涉及13,920名女性和74,967个疗程的多渠道研究，也衡量了Marvelon对于皮肤状况的影响。 经研究发现：6个疗程过后，超过80%的原有的痤疮消失了，皮脂溢也同样消失了。 In addition to beneficial effects of Mercilon on cycle control and dysmenorrhea, Serfaty et al proved the beneficial effect of Mercilon on the premenstrual syndrome (PMS). In this multicenter trial, 20.3% of the 467 women reported to experience PMS at baseline. After 1 cycle of using Mercilon, PMS was present in only 12.1% of the women. PMS had disappeared in 13.4%, while newly occurring PMS was reported in only 5.7%. This graph clearly shows the beneficial effect of Mercilon on premenstrual syndrome. OC在PCOS不孕症中的应用 36岁、对CC不敏感的PCOS 雄激素偏高 可先用3－6个月OC 促排卵治疗 自然排卵 妈富隆?治疗PCOS PCOS 139例，共计198个周期 观察组：经Marvelon前期治疗（2-3个周期）后，再诱导排卵 对照组：直接诱发排卵 组别 例数 促排卵例数 促排卵周期数 促排卵周期排卵率 促排卵患者妊娠率 观察组 73 59 110 73.64%(81/110) 49.15%(29/59) 对照组 66 66 133 57.89%(77/133)