甲亢英文.pptVIP

山东农业大学 计算机科学系 Hyperthyroidism Introduction 85% Male to female 1:4-6 Chief clinical findings Nervous system: Nervousness, emotional lability, irritability, fine tremor of hands. Cardiovascular: Palpitation, tachycardia, atrial fibrillation, widened pulse pressure. Gastrointestinal: Increased appetite, Hyperdefecation, diarrhea Hematologic system: Moderate neutropenia, mild anemia. Others: Muscle atrophy, oligomenorrhear. Diagnosis Antithyroid drugs: Thionamides Radioactive iodine(131I) Thyroid surgery Thionamides : 谢 谢！ 复旦大学附属中山医院 复旦大学附属中山医院 Definition：Function of thyroidism metabolism many systems excitability Most common is diffuse toxic goiter (Graves disease, GD) , 85% Various causes Graves disease: 85% Autonomous toxic adenomas of the thyroid: Plummers disease or toxic multinodular goiter Jodbasedow disease(Iodine-induced HT) Functioning thyroid carcinoma TSH hypersecretion by the pituitary Struma ovarii Subacute thyroiditis Hashimotos thyroiditis Thyrotoxicosis factitia Carcinoma accompanying thyrotoxicosis Graves disease Symptoms due to Hypermetabolism goitor Ophthalmopathy Abnormal immune: TRAb Heredity Infection: Molecular mimicry Cytokine Superantigen Spirit irritation Etiology and Pathophysiology Clinical manifestation Common Symptoms due to Hyper metabolism: Heat intolerance, excessive perspiration, warm moist smooth skin, fatigue, weight loss. Goitor: Enlargement or nodules Ophthalmopathy: A sense of irritation in eyes, excessive tearing, exophthalmos, blurred vision, easy tiring of the eyes, double vision. 图1 图2 图3 图4 Clinical manifestation Common Clinical manifestation Exceptive T3 Toxicosis: initial phases or a relapse of GD T4 Toxicosis Apathetic hyperthyroidism Thyrotoxic crisis Thyrotoxic myopathy: Hypokalemic periodic paralysis etc. Hyperthyroidism in pregnancy Cardiac complications: atrial fibrillation Laboratory Diagnosis Seru