Imaging neural architecture of the brain based on its multipole magnetic response（基于多极磁响应的脑神经结构成像）.pdfVIP

NIH Public Access Author Manuscript Neuroimage . Author manuscript; available in PMC 2014 February 15. N Published in final edited form as: I H Neuroimage . 2013 February 15; 67: 193–202. doi:10.1016/j.neuroimage.2012.10.050. - P A A u Imaging neural architecture of the brain based on its multipole t h o magnetic response r M a a,b,* a n Chunlei Liu and Wei Li u a s Brain Imaging and Analysis Center, School of Medicine, Duke University, Durham, NC, USA c r i b p Department of Radiology, School of Medicine, Duke University, Durham, NC, USA t Abstract Although magnetic fields interact weakly with biological tissues, at high fields, this interaction is sufficiently strong to cause measurable shifts in the Larmor frequency among various tissue types. While measuring frequency shift and its anisotropy has enabled NMR spectroscopy to determine structures of large molecules, MRI has not been able to fully utilize the vast information existing N I in the frequency to elucidate tissue microstructure. Using a multipole analysis of the complex MRI H - signal in the Fourier spectral space, we developed a fast and high-resolution method that enables P A the quantification of tissue’s magnetic response with a set of magnetic susceptibility tensors of A various ranks. The Fourier spectral space, termed p-space, can be generated by applying field u t gradients or equivalently by shifting the k-space data in various directions. Measuring these h o tensors allow