(内科学教材）03.1 Leukemia（已翻译）.pptxVIP

Leukemia【白血病】loushifeng New wordsGruanulocyte 粒细胞Neutrophil 嗜中性细胞Self –renewal自我更新Differrentiate 分化Eosnophils 嗜酸性细胞Myeloblast 原粒细胞Basophils 嗜碱性细胞Erythrocyte 红细胞Erythroblast原红细胞Megakaryoblast原巨核Thrombocyte 血小板Stem cell干细胞Lymphoblast 原淋巴细胞Lymphocyte 淋巴细胞Proliferation增殖Anemia 贫血Hemorrhage 出血Infection 感染Hematopoiesis造血Peripheral Blood周围血Bone marrow 骨髓 Leukemialoushifeng IntroductionDefinition History 1827 Velpeal with his blood “like gruel【粥】” 1845 Benett ，Edinburg, England. with “color and consistency【稠度】 of their blood; Virchow ，Berlin,Germany introduced leukemia from Greek meaning white bloodIntroductionDefinition Leukemia is a group of clonal malignant 【恶性的】diseases developed form hematopoietic stem cell【造血干细胞】 or progenitor cell【祖细胞】. that lead to Suppression of normal hematopoiesis Infiltrations【浸润】 in outside of bonemarrow 【骨髓】Introduction Classification Acute Leukemia Acute lymphocytic【淋巴的】 Leukemia（ALL） Acute Myeloid【骨髓的】 Leukemia （AML） Chronic Leukemia Chronic Myeloid Leukemia（CML） Chronic lymphocytic Leukemia（CLL）Leukemia uncommon in clinicIntroductionIncidenceThe total morbidity【发病率】 : 2.67/100 thousands higher than the chance to win a lottery【数千的】(1/400 thousands ) 男：女=1.8：1IntroductionPrognosis 100%BMTCHEMO01 2 3 4 5 YEARIntroductionEtiology and Pathogenesis Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning Ionizing radiation【电离辐射】 swellNational Cancer Institute (NCI)?researcher Robert Gallo reports isolation of an AIDS virus he calls HTLV-IIIIntroductionEtiology and Pathogenesis Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Benzene poisoning Ionizing radiation Normal Stem cellMutation（突变）Leukemic stem cell(白血病干细胞)Progenitor cells(祖细胞)Blast cell（母细胞） IntroductionPathogenesis（病理机制）IntroductionProperties of LSC: self-renewal,quiescent（停滞，静止）,proliferation（增殖）,multi-potentiality? , differentiation damaged（分化障碍） . Immunophenotype（免疫表型） of LSC : AML CD