2型糖尿病患者糖尿病肾病与血脂相关性分析.docVIP

2型糖尿病患者糖尿病肾病与血脂相关性分析 　　【摘要】 目的 通过观察2型糖尿病患者尿微量白蛋白与血脂的相关性，探讨血脂异常与糖尿病肾病的关系。方法 选取48例2型糖尿病患者，根据尿mAlb/Cr结果分为无微量白蛋白尿组(DM组)及伴有微量白蛋白尿组(DN组)。检测甘油三酯 (TG)、总胆固醇 (TC)、高密度脂蛋白 (HDL)、低密度脂蛋白(LDL)等，观察各项指标与尿mAlb/Cr的关系。对照组20例。结果 对照组TG、TC、LDL与DN组比较，均明显降低 (P 　　【关键词】 　　2型糖尿病；尿微量白蛋白；血脂异常 　　?? 　　 　　Correlation of diabetic nephropathy with blood fat in patients with type 2 diabetes mellitus 　　 　　ZHAO Jing, MING Hui, HUANG Hai?quan. Department of Endocrine,Tongling people?s Hospital,Anhui 244000,China 　　? 　　 　　 　　【Abstract】 Objective To observe the correlation of urinary microalbumin with blood fat in patients with type 2 diabetes mellitus in order to explore the relationship between dyslipidemia and diabetic nephropathy. Methods Forty?eight patients with type 2 diabetes mellitus were enrolled, then diabetic patients were divided into DM group (without microalbuminuria) and DN group (with microalbuminuria) according to urinary albumin/creatinine ratio. The following factors were analyzed,such as triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and so on. Meanwhile, the relationship between such factors and urinary microalbumin was investigated. Twenty healthy people were selected as normal control group. Results Compared with DN group, TG, TC and LDL were signficanfly lower in normal control group (P2.5 mg/mmol为阳性，女性尿mAlb/Cr3.5 mg/mmol为阳性。根据尿mAlb/Cr结果将患者分为无微量白蛋白尿组(DM组) 及伴有微量白蛋白尿组(DN组)。DM组28例，其中男15例，女13例，平均年龄(55.7±9.9)岁，体重指数(21.31±1.71)kg/m??2?。DN组20例，其中男12例，女8例，平均年龄(56.8±15.3)岁，体重指数(22.26±2.02)kg/m??2?。选择20例正常健康者作为对照组，男9例, 女11例，平均年龄(54.9±6.9)岁，体重指数(21.41±2.28)kg/m??2?。3组在性别、年龄、体重指数上差异无统计学意义(P0.05)。? 　　2 结果? 　　2.1 3组患者组间年龄、性别、体重指数等相关指标比较差异无统计学意义(P0.05)，提示3组患者具有可比性。? 　　2.2 对照组TG、TC、LDL与DN组比较，均明显降低 (P0.05)。? 　　 　　 　　表1 　　 　　3组各指标比较 (x±s) 　　? 　　 　　 　　组别例数TC(mmol/L)TG(mmol/L)HDL(mmol/L)LDL(mmol/L)FBG(mmol/L)mAlb/Cr(mg/mmol) 　　DM284.45±0.811.78±1.361.26±0.431.95±0.619.71±3.671.24±0.53 　　DN206.34±2.18??1.2?3.44±3.01??1.