药理学 Pharmacology(-96).pptVIP

药理学总论General Principles of Pharmacology 1.2 药物的物理性质 固体药 - oral route 阿司匹林（aspirin ） 液体药物 - oral route, IM, SC 乙醇（ ethanol ） 药物溶液 - oral route, IM, SC , iV . 挥发性药物 - inhalation 亚硝酸异戊酯（ amylnitrite） Many drugs are weak acids or bases pH differences in the body may alter the degree of ionization of drug 1.3 药物分子大小 Most drugs have molecular weights between 100 and 1,000 1.4 药物与受体结合力 共价键（Covalent bond ）– very strong, not reversible，酚苄明 静电键（Electrostatic bond ）-- ionic molecules, hydrogen bonds, dipole interaction (Van der waals Forces) 疏水键（Hydrop