脑钠素及水通道蛋白-2与原发性高血压关系的分析-analysis of the relationship between brain natriuretic peptide and aquaporin - 2 and essential hypertension.docxVIP

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脑钠素及水通道蛋白-2与原发性高血压关系的分析-analysis of the relationship between brain natriuretic peptide and aquaporin - 2 and essential hypertension.docx

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脑钠素及水通道蛋白-2与原发性高血压关系的分析-analysis of the relationship between brain natriuretic peptide and aquaporin - 2 and essential hypertension

相关，提示 BNP 有可能通过细胞信使分子之间的相互作用影响了 AQP2的表达；4.NLVH 组尿液 AQP2 浓度高于正常对照组，但与血浆 BNP 浓度、血压水平无明显相关性。关键词：原发性高血压；脑钠素；水通道蛋白－2.Effects of brain natriuretic peptide and urinary aquaporin-2 in essential hypertensionABSTRACTObjectives: To observe the variation of the concentrations of plama brain natriuretic peptide (p-BNP)and the urinary aquaporin-2(u-AQP2) in the patients with essential hypertension (EH) and the control subjects,then to incesting the effects of (p-BNP) and (u-AQP2) in EH’s pathogenesy,it can provide some theory basic for EH diagnosis and treatment.Methods: According to LVMI,147 patients with EH were divided into two groups,including left ventricular hypertrophygroup(LVH) and non left ventricular hypertrophy group(NLVH),and the patients were divided into three subgroups by the blood pressure grades in the two groups—the grade 1 hypertension subgroup, the grade 2 hypertension subgroup, the grade 3 hypertension subgroup. The patients were compared against 30 normal control subjects. In all subjects, the plama concentration of BNP were detected by enzyme linked immunosorbent assay(ELISA), the concentration of u-AQP2 were detected by indirect enzyme linked immunosorbent assay (indirect ELISA), and the mean arterial pressure(MAP) was measured. Analyzed all the measured value by using the 13.0 SPSS software and then discussthe relationship among u-AQP2, p-BNP and MAP.Results: 1.The concentration of u-AQP2 (P0.01) and p-BNP(P0.01) in the patients with LVH were higher than that in control subjects and the patients with NLVH. The concentration of u-AQP2 and p-BNP in the patients in the three different subgroups with LVH werehigher than that in control subjects and the patients with NLVH in the same blood pressure grade(P0.05),that inceased along with the blood pressure grade(P0.05). It had positive correlation among u-AQP2,p-BNP and MAP(P0.05). 2. The concentration of u-AQP2 (P0.05) and p-BNP(P0.05) in the patients with NLVH werehigher than that in control subjects. Thoug