明胶-壳聚糖微囊的制备及其体内研讨.pdfVIP

中文摘要 本文第一部分的研究内容是以明胶、壳聚糖为壁材，采用复凝聚法分别制备 了当归油和丁香油微囊，用以比较研究不同芯材对明胶．壳聚糖为壁材制备微囊的 影响。对两种“同壳异核”微囊的评价结果得出：(1)两种微囊的综合性能(产 率、包封率、抗氧化率及缓释性能)均比较好；(2)该明胶。壳聚糖当归油微囊工 艺能够包埋许多具有一定性质的药物。 本文第二部分的研究内容是比较“同壳异核”、“同核异壳”微囊在动物体内 释药的过程。分析五种微囊(明胶．壳聚糖当归油微囊、明胶．壳聚糖丁香油微囊、 海藻酸钠．壳聚糖丁香油微囊、羧甲基纤维素钠．壳聚糖丁香油微囊、阿拉伯胶．壳 聚糖丁香油微囊)在大鼠体内的释药过程，得出结论：(1)五种微囊均具有一定 缓释作用；(2)明胶。壳聚糖微囊的综合性能最优。 关键词：明胶；壳聚糖；当归油；丁香油；星点设计；体内评价 Abstract Abstract Inthis oiland with paper，fistly,wepreparedangelica eugenolmicrocapsulesgelatin method．Theaimisthatfindouttheeffect and coacervate chitosan(wallmaterials)by differentcores．Wedraw onthe and of with prepared propertyprocessmicrocapsules conclusions thetwokindsofmicrocapsules：(1)thecomprehensive bycomparing rateand efficiency，antioxidation includingyield，encapsulation performance sustained．releaseof wereall of microcapsulesfavorable；(2)theprocess performance oil canembedalotof some microcapsule drugpossessed gelatin-ehitosanangelica properties． have therelease invivo the investigated process bycomparing Secondly，we of‘‘samecoredifferentshell’’and‘‘sameshelldifferent microcapsules core”．Analyse therelease offivekindsof oil angelica process microc