卡维地洛对正常青年男性血压影响.docVIP

卡维地洛对正常青年男性血压影响 　　【摘要】 目的探讨健康男性青年服用β受体阻滞剂卡维地洛后不同血药浓度下静息坐位血压与用药前比较有无显著性变化,以评价卡维地洛的降压特点,为临床用药提供试验依据。方法 对20名健康男性青年在服用卡维地洛20 mg前及服药后0.5、1、2、3、4、6、8、10、24 h分别测血药浓度, 并监测各时间点坐位静息血压,并将数据进行统计分析。结果 血压变化与血药浓度的变化没有明显相关性,与用药前血压比较有显著性降低,即P 　　【关键词】 卡维地洛;收缩压;舒张压;血药浓度;健康男性青年 　　 　　The influence of carvedilol on blood of young men in good health 　　 　　LI Yan-jing,WANG Yan,LI Li,et al.Department of Internal Medicine,Jinan Hospital,Jinan,Shandong 250013,China 　　 　　【Abstract】 Objective To investigate the effects of carvedilol on blood pressure changes, and to evaluate the blood pressure lowing property of carvedilol.To supply clinical base for the blood pressure lowing of carvedilol. Methods Abstract randomly 20 young men in good health. Everyone was asked to take 20 mg carvedilol.Their blood pressure of sitting during rest time were measured before and after taking the drug, respectively at 0.5, 1, 2, 3, 4, 6, 8, 10, 24 h.Meantime their drug blood concentrations were measured at different time point. Results There were significant differences between the blood pressure value before and after administration,and there were no sigificant correlation between the changes of blood pressure and that of the drug blood concentrations.Conclusion Carvedilol has brilliant blood pressure lowering activity in the healthy young men. The blood pressure lowing property of Carvedilol is fast and prolonging.They have good tolerance to the drug. 　　【Key words】 Carvedilol;SBP; DBP;Drug blood concentrations; Young man in good health 　　 　　作者单位:250013 山东省济南医院内一科 　　 　　卡维地洛是一种新型第三代的β受体阻制剂,对心脏β1,β2,血管α1受体都有阻断作用,但没有内源性拟交感活性,在高浓度时对钙离子通道也有阻断作用,同时它还具有抗氧化活性。[1]卡维地洛可通过阻滞突触后膜α1受体,扩张血管,降低外周血管阻力;通过阻滞β受体,抑制肾脏分泌肾素,阻断肾素-血管紧张素-醛固酮系统,产生降压作用。临床主要用于轻中度高血压的??疗。本研究观察20位健康志愿者服用卡维地洛20 mg后0.5、1、2、3、4、6、8、10、24 h的血药浓度变化及血压变化。以评价卡维地洛的降压特点,为临床用药提供试验依据,现报告如下。 　　1 资料和方法 　　1.1 一般资料 　　1.1.1 受试者选择 随机抽取20位医学院四年级学生,全部为男性,年龄21~25岁,平均(22.8±1.105)岁,不嗜酒;身体健康,无心、肝、肾、消化道、代谢异常等病史,并进行健康体检(血、尿常规及血生化、超声心动图、心胸透视、心电图检查均正常);无药物过敏和神经系统疾病史;无体位低