Differentiation of the Neuropsychological Features of MCI ：对MCI患者神经心理学特征的分化.ppt

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2018-06-05 发布于浙江
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Differentiation of the Neuropsychological Features of MCI ：对MCI患者神经心理学特征的分化.ppt

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Differentiation of the Neuropsychological Features of MCI ：对MCI患者神经心理学特征的分化

Tr?ster 2009 MCI in Lewy Body Disorders: Definition, Frequency, Progression and Differentiation from Other MCI Alexander I. Tr?ster, Ph.D. Department of Neurology University of North Carolina, Chapel Hill Overview Nomenclature of Lewy body disorders Factors leading to consideration of “MCI” as an entity in Parkinson’s disease (PD) Potential benefits of identifying MCI in PD Frequency and subtypes of MCI in PD Conversion of MCI to PDD and DLB Dementia and the neuropsychological characteristics of the PDD prodrome Comparisons of neuropsychological characteristics of early PDD/DLB and Alzheimer’s disease Challenges facing the concept of MCI in Lewy body disorders Nomenclature of Lewy Body DisordersDLB/PDD Work Group (Lippa et al. 2007) Lewy body disorders Parkinson’s disease (PD) Parkinson’s disease with dementia (PDD) Dementia with Lewy bodies (DLB) Lewy body dementias Parkinson’s disease with dementia (PDD) Dementia with Lewy bodies (DLB) Distinction in temporal sequence of onset of motor symptoms and dementia in PDD and DLB retained in recent criteria (12 Month Rule) Cognitive Impairment in PD Cognitive changes in PD without dementia recognized for decades Cognitive changes near time of diagnosis recognized only recently (Foltynie et al. 2004, Muslimovic et al., 2005) First to refer to MCI in PD was review by Fernandez et al. 2005 Possible Factors Prompting Consideration of MCI in PD Acknowledgement of MCI heterogeneity and subtypes (Petersen 2004) Recognition of a) heterogeneous, and b) very early cognitive decrements in PD (Muslimovic et al. 2005) Neuropathologic staging of PD compatible with pre-diagnostic non-motor symptoms (Braak et al.2003) Possible Advantages of MCI Diagnosis in PD Early detection and treatment of cognitive decline, and consequent enhancement of functioning Evaluation of DLB/PDD distinction Greater precision in identifying course of cognitive decline, risk factors for these declines, and underlying mechanisms Evaluation and MCI