Drug Resistant Epilepsy Diagnostic and Treatment Options：耐药性癫痫的诊断和治疗.ppt

下载文档 降价啦

4
0
约8.24千字
约 28页
2018-06-05 发布于浙江
举报
版权申诉
保障服务

Drug Resistant Epilepsy Diagnostic and Treatment Options：耐药性癫痫的诊断和治疗.ppt

1、本文档共28页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

Drug Resistant Epilepsy Diagnostic and Treatment Options：耐药性癫痫的诊断和治疗

Drug Resistant Epilepsy:Diagnostic and Treatment Options Mark A. Granner, MD Medical Director, Epilepsy Monitoring Unit Co-Director, Iowa Comprehensive Epilepsy Program Professor and Vice Chair for Clinical Programs Department of Neurology University of Iowa Overview Definitions and statistics Treatment options for drug resistant epilepsy AEDs, diet, VNS Introduction to epilepsy surgery The multidisciplinary approach to epilepsy care The Iowa Comprehensive Epilepsy Program Iowa Comprehensive Epilepsy Program Definitions Seizure An episode of altered behavior or awareness Associated with too much excitation of a population of nerve cells (neurons) Epilepsy The tendency to have recurrent, unprovoked seizures (brain makes seizures happen) Acute symptomatic (provoked) seizure A seizure occurring in the setting of some systemic provoking factor (normal brain, body makes seizures happen) Iowa Comprehensive Epilepsy Program Definitions Acute repetitive seizures (“cluster”) A period of increased severity or frequency of seizures in an epilepsy patient Status epilepticus A single prolonged seizure ( 5-10 min) Repeated seizures without recovery to baseline SUDEP Sudden unexpected death in epilepsy patients 1-6 per 1000 patients per year Probably under recognized, under reported Needs further study Iowa Comprehensive Epilepsy Program Definitions Drug resistant epilepsy Failure of at least TWO seizure medications to completely control seizures Appropriately chosen for seizure type Taken as prescribed Well tolerated (not failed due to side effects) Iowa Comprehensive Epilepsy Program Drug Resistant Epilepsy 470 patients with previously untreated epilepsy Seizure-free to 1st medication 47% Seizure-free to 2nd medication 13% Seizure-free to 3rd medication or beyond 4% 36% of epilepsy patients are drug resistant! The new generation of medications are generally safer (fewer side effects), but are not significantly more effective. Kwan P, Brodie M. NEJM 2000; 342(5) Iowa Comprehen