型利钠肽心力衰竭诊治中的进展杨跃进课件.ppt

在治疗过程中，不同剂量组的患者肺动脉楔压均有显著的下降，患者的病情明显好转。 谢 谢 ！ * The Triage? BNP Test is indicated for use as an aid in the diagnosis of congestive heart failure. * Listed here are the three common natriuretic peptides. Structurally, the natriuretic peptides are similar. All have a 17 AA ring structure with 11 identical AA. This ring structure is essential for receptor binding (Guanylate cyclase linked receptor). The first natriuretic peptide that was identified in the late 1960s was the Atrial Natriuretic Peptide , a 28-amino acid hormone found predominantly in the atrium of the heart. ANP is increased in volume overload conditions in normal patients, as well as patients with CHF. The B-type, or formerly called Brain Natriuretic Peptide, has been found to be a more useful marker for congestive heart failure because the hormone is elevated in patients with congestive heart failure. BNP is secreted from the ventricles of the heart in response to ventricular stretch and volume overload. BNP has been synthesized and developed as a therapeutic tool for use in congestive heart failure. The C-type natriuretic peptide is found in the endothelium of the heart, has a very low concentration in plasma, and is not elevated in CHF. Other members of the natriuretic peptide family such as Urodilatin are still being identified and characterized. This family of hormonally active peptides clearly has a regulatory role in cardiovascular disease. The Triage? BNP Test is indicated for use as an aid in the diagnosis of congestive heart failure. * This slide lists the origin and stimulus for the release of the natriuretic peptides. Note that BNP is specifically released from the ventricles of the heart in response to ventricular stretch and volume overload. The Triage? BNP Test is indicated for use as an aid in the diagnosis of congestive heart failure. * This slide describes the physiologic effects of the renin angiotensin aldosterone system (RAA system) and the natriuretic peptid