丁苯肽对急性脑梗死后认知功能和生活质量改善作用.docVIP

丁苯肽对急性脑梗死后认知功能和生活质量改善作用 　　[摘要] 目的 探讨丁苯肽对急性脑梗死后认知功能和生活质量的改善作用。 方法 选择80例急性脑梗死后认知功能障碍患者，随机分为观察组和对照组。两组患者均酌情予以控制血压、血糖和血脂，血小板聚集和营养脑细胞等基础治疗。观察组患者加用丁苯肽胶囊200 mg/次，4次/d，连用8周。对照组患者加用尼莫同片30 mg/次，3次/d，连用8周。观察并比较两组患者治疗前后认知功能和生活质量的变化。 结果 治疗8周后，两组患者MMSE评分、WMS评分和MOCA评分[（23.72±4.58）、（38.25±5.96）、（24.06±5.19）、（27.45±4.92）、（44.64±6.02）、（27.92±5.35）分]均较治疗前[（18.97±4.45）、（33.51±5.85）、（19.31±4.19）、（19.03±4.37）、（33.94±6.17）、（18.97±4.47）分]明显上升（t = 2.47、2.25、2.44、3.05、2.82、3.17，P 　　[关键词] 急性脑梗死；丁苯肽；认知功能；生活质量 　　[中图分类号] R743.3 [文献标识码] A [文章编号] 1673-7210（2013）11（a）-0079-03 　　Improving effect of Butylphthalide on cognitive function and life quality in patients after suffering acute cerebral infarction 　　WEI Ying LI Haijun 　　The Second Department of Neurology， Taizhou Municipal Hospital Municipal Hospital Affiliated to Medical College of Taizhou University， Zhejiang Province， Taizhou 318000， China 　　[Abstract] Objective To discuss Butylphthalides improving effect for cognitive function and life quality in patients after suffering acute cerebral infarction. Methods 80 cases of cognitive dysfunction patients after suffering acute cerebral infarction were selected and divided into observation group and control group. The patients in two groups were given basic treatment like the control of blood pressure， blood sugar and blood fat， platelet aggregation （PA）， brain cells nutrition and etc. as needed. The patients in observation group were given 200 mg Butylphthalide Soft Capsules per time， 4 times daily for 8 weeks. The patients in control group were given 30 mg Nimodipine three times daily for 8 weeks. The changes of cognitive function and life quality of patients in two groups before and after medical treatment were observed and compared. Results After 8 weeks medical treatment， the MMSE， WMS and MOCA scores of patients in two groups [（23.72±4.58）， （38.25±5.96）??? （24.06±5.19）， （27.45±4.92）， （44.64±6.02）， （27.92±5.35） points] rose obviously than before [（18.97±4.45）， （33.51±5.85）， （19.31±4.1