功能性食品-第六章 维生素E.ppt

* * * * O2- = superoxide radical LOO* = peroxy radical LH = unsaturated fatty acid L* = carbon centered radical RH = organic nonlipid compound R* = carbon centered nonlipid radical H2O2 = hydrogen peroxide ROO* = nonlipid peroxy radical LOOH = lipid peroxides * EH = vitamin E AH2 = vitamin C SOD = superoxide dismutase GSH = reduced glutathione GSSG = oxidized glutathione O2- = superoxide radical LOO* = peroxy radical LH = unsaturated fatty acid L* = carbon centered radical RH = organic nonlipid compound R* = carbon centered nonlipid radical H2O2 = hydrogen peroxide ROO* = nonlipid peroxy radical ROOH = nonlipid peroxides LOOH = lipid peroxides * * Table 3 Effects of Antioxidants on UV-Induced Skin Tumor Development in Studies in Mice Treatment Initiated Prior to UV Irradiation Results Ref. Topical vitamin C, vitamin E or 2,4 hexadien-1-ol & an antiinflammatory agent Greatly reduced incidence of skin tumors 25 Topical vitamin E, oral vitamin E Significantly delayed onset and decreased number of skin tumors 26 Topical vitamin E Incidence of skin cancer was 81% in controls & 42% in treated animals 47 Topical vitamin E acetate or succinate No inhibition of skin cancer 48 Topical vitamin E acetate Delayed tumor formation & yield at 20 weeks, but not at 30 weeks 49 Topical vitamin E Inhibition of skin cancer 50 2.维生素E和硒协同清除自由基 维生素E和硒都是自由基清除剂，维生素E有节省或部分替代硒的功能，硒也能治疗维生素E 的某些缺乏症，维生素E 和硒之间有协同作用。 维生素E结合于生物膜上能保护膜免受自由基攻击而出现的过氧化损伤，硒则通过GSH-Px等破坏过氧化物，防止新的自由基形成及其对不饱和脂肪酸的侵袭。也就是说， GSH-Px能分解已形成的过氧化物(如ROOH和H2O2), 有效地阻止了可能引发脂质过氧化的羟自由基(OH?)和单线态氧(1O2)的生成；而维生素E能中断脂质过氧化的连锁反应，减少氢过氧化物的生成。两者之间表现出相互节省效应，其中一种成分的生理需求可用另一种加以补偿。 Selenium GSH peroxidase and phospholipid hydroperoxide GSH peroxidase GSH Peroxidase ROOH + 2 GSH -------------------? ROH + GSSG + H2O Roles for micronutrients in the system for the defense against free radical damage Physical/Chemical Agents Fatty acid Radical+oxygen Fatty acid peroxide O2.- +2H (s